Mapping of DNA markers close to the fraglle site on the human X chromosome at Xq25-3

M. Patterson, S. Kenwrick, S. Thibodeau, K. Faulk, M. G. Mattei, J. F. Mattei, K. E. Davies

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

We report the identification of a new RFLP detected by the DNA probe MN12, which is linked to both the fragile site on the X chromosome at Xq27-3 and the highly polymorphic locus detected by Stl4 (DXS52). In situ mapping confirms the localisation of MN12 distal to the fragile site. A detailed physical analysis of this region of the X chromosome using pulsed-field gel electrophoresis has shown that MN12, Stl4 and DX13 (DXS15) are physically linked within a region of tyyOkb. A long range restriction map around the MN12 locus reveals at least two candidate HTF islands, suggesting the existence of expressed sequences in this region.

Original languageEnglish (US)
Pages (from-to)2639-2651
Number of pages13
JournalNucleic acids research
Volume15
Issue number6
DOIs
StatePublished - Mar 25 1987

ASJC Scopus subject areas

  • Genetics

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    Patterson, M., Kenwrick, S., Thibodeau, S., Faulk, K., Mattei, M. G., Mattei, J. F., & Davies, K. E. (1987). Mapping of DNA markers close to the fraglle site on the human X chromosome at Xq25-3. Nucleic acids research, 15(6), 2639-2651. https://doi.org/10.1093/nar/15.6.2639