TY - GEN
T1 - Mapping hippocampal degeneration in 400 subjects with a novel automated segmentation approach
AU - Morra, Jonathan H.
AU - Tu, Zhuowen
AU - Apostolova, Liana G.
AU - Green, Amity E.
AU - Avedissian, Christina
AU - Madsen, Sarah K.
AU - Parikshak, Neelroop
AU - Hua, Xue
AU - Toga, Arthur W.
AU - Jack, Clifford R.
AU - Schuff, Norbert
AU - Weiner, Michael W.
AU - Thompson, Paul
PY - 2008
Y1 - 2008
N2 - We automatically segmented the hippocampus in 400 brain MRI scans from the Alzheimer's Disease (AD) Neuroimaging Initiative, combining AdaBoost with a novel model, the Auto Context Model (ACM). Trained on 21 hand-labeled segmentations, ACM created binary hippocampus maps in 100 controls, 200 with mild cognitive impairment (MCI), and 100 AD subjects, (age: 75.8+/-6.6SD). A radial atrophy mapping technique computed average parametric surface models and local statistics of atrophy. We visualized correlations between regional atrophy and diagnosis (MCI v. controls: p = 0.008; MCI v. AD: p = 0.001), mini-mental state exam scores, and clinical dementia rating scores (CDR; all p < 0.0001, corrected). Based on false discovery rate curves in gradually reduced samples, 40 subjects were sufficient to correlate atrophy and CDR scores; MCI and AD were distinguishable with N = 304.
AB - We automatically segmented the hippocampus in 400 brain MRI scans from the Alzheimer's Disease (AD) Neuroimaging Initiative, combining AdaBoost with a novel model, the Auto Context Model (ACM). Trained on 21 hand-labeled segmentations, ACM created binary hippocampus maps in 100 controls, 200 with mild cognitive impairment (MCI), and 100 AD subjects, (age: 75.8+/-6.6SD). A radial atrophy mapping technique computed average parametric surface models and local statistics of atrophy. We visualized correlations between regional atrophy and diagnosis (MCI v. controls: p = 0.008; MCI v. AD: p = 0.001), mini-mental state exam scores, and clinical dementia rating scores (CDR; all p < 0.0001, corrected). Based on false discovery rate curves in gradually reduced samples, 40 subjects were sufficient to correlate atrophy and CDR scores; MCI and AD were distinguishable with N = 304.
KW - AdaBoost
KW - Alzheimer's disease
KW - Hippocampal segmentation
KW - Magnetic resonance imaging
UR - http://www.scopus.com/inward/record.url?scp=51049107703&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=51049107703&partnerID=8YFLogxK
U2 - 10.1109/ISBI.2008.4541001
DO - 10.1109/ISBI.2008.4541001
M3 - Conference contribution
AN - SCOPUS:51049107703
SN - 9781424420032
T3 - 2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, Proceedings, ISBI
SP - 336
EP - 339
BT - 2008 5th IEEE International Symposium on Biomedical Imaging
T2 - 2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI
Y2 - 14 May 2008 through 17 May 2008
ER -