Mapping hippocampal degeneration in 400 subjects with a novel automated segmentation approach

Jonathan H. Morra, Zhuowen Tu, Liana G. Apostolova, Amity E. Green, Christina Avedissian, Sarah K. Madsen, Neelroop Parikshak, Xue Hua, Arthur W. Toga, Clifford R. Jack, Norbert Schuff, Michael W. Weiner, Paul Thompson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Scopus citations

Abstract

We automatically segmented the hippocampus in 400 brain MRI scans from the Alzheimer's Disease (AD) Neuroimaging Initiative, combining AdaBoost with a novel model, the Auto Context Model (ACM). Trained on 21 hand-labeled segmentations, ACM created binary hippocampus maps in 100 controls, 200 with mild cognitive impairment (MCI), and 100 AD subjects, (age: 75.8+/-6.6SD). A radial atrophy mapping technique computed average parametric surface models and local statistics of atrophy. We visualized correlations between regional atrophy and diagnosis (MCI v. controls: p = 0.008; MCI v. AD: p = 0.001), mini-mental state exam scores, and clinical dementia rating scores (CDR; all p < 0.0001, corrected). Based on false discovery rate curves in gradually reduced samples, 40 subjects were sufficient to correlate atrophy and CDR scores; MCI and AD were distinguishable with N = 304.

Original languageEnglish (US)
Title of host publication2008 5th IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro, Proceedings, ISBI
Pages336-339
Number of pages4
DOIs
StatePublished - Sep 10 2008
Event2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI - Paris, France
Duration: May 14 2008May 17 2008

Publication series

Name2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, Proceedings, ISBI

Other

Other2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI
CountryFrance
CityParis
Period5/14/085/17/08

Keywords

  • AdaBoost
  • Alzheimer's disease
  • Hippocampal segmentation
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Biomedical Engineering

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  • Cite this

    Morra, J. H., Tu, Z., Apostolova, L. G., Green, A. E., Avedissian, C., Madsen, S. K., Parikshak, N., Hua, X., Toga, A. W., Jack, C. R., Schuff, N., Weiner, M. W., & Thompson, P. (2008). Mapping hippocampal degeneration in 400 subjects with a novel automated segmentation approach. In 2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, Proceedings, ISBI (pp. 336-339). [4541001] (2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, Proceedings, ISBI). https://doi.org/10.1109/ISBI.2008.4541001