Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders

The Mood Disorders Precision Medicine Consortium (MDPMC)

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Substantial research progress can be achieved if available clinical datasets can be mapped to the National Institute of Mental Health Research-Domain-Criteria (RDoC) constructs. This mapping would allow investigators to both explore more narrowly defined clinical phenotypes and the relationship of these phenotypes to biological markers and clinical outcomes approximating RDoC criteria. Methods: Using expert review and consensus, we defined four major depression phenotypes based on specific RDoC constructs. Having matched these constructs to individual items from the Hamilton Depression Rating Scale and Quick Inventory of Depressive Symptomatology, we identified subjects meeting criteria for each of these phenotypes from two large clinical trials of patients treated for major depression. In a post hoc analysis, we evaluated the overall treatment response based on the phenotypes: Core Depression (CD), Anxiety (ANX), and Neurovegetative Symptoms of Melancholia (NVSM) and Atypical Depression (NVSAD). Results: The phenotypes were prevalent (range 10.5–52.4%, 50% reduction range 51.9–82.9%) and tracked with overall treatment response. Although the CD phenotype was associated with lower rates of remission in both cohorts, this was mainly driven by baseline symptom severity. However, when controlling for baseline severity, patients with the ANX phenotype had a significantly lower rate of remission. Limitations: The lack of replication between the studies of the phenotypes’ treatment prediction value reflects important variability across studies that may limit generalizability. Conclusion: Further work evaluating biological markers associated with these phenotypes is needed for further RDoC concept development.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalJournal of Affective Disorders
Volume238
DOIs
StatePublished - Oct 1 2018

Fingerprint

Mood Disorders
Depression
Phenotype
Research
Anxiety
Biomarkers
National Institute of Mental Health (U.S.)
Depressive Disorder
Consensus
Therapeutics
Research Personnel
Outcome Assessment (Health Care)
Clinical Trials
Equipment and Supplies

Keywords

  • Anxiety
  • Core depression
  • Major depressive disorder
  • Neurovegetative symptoms of melancholia and atypical depression
  • Research domain criteria

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders. / The Mood Disorders Precision Medicine Consortium (MDPMC).

In: Journal of Affective Disorders, Vol. 238, 01.10.2018, p. 1-7.

Research output: Contribution to journalArticle

@article{aabcc692270f42d89c1fb2b330a209ac,
title = "Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders",
abstract = "Background: Substantial research progress can be achieved if available clinical datasets can be mapped to the National Institute of Mental Health Research-Domain-Criteria (RDoC) constructs. This mapping would allow investigators to both explore more narrowly defined clinical phenotypes and the relationship of these phenotypes to biological markers and clinical outcomes approximating RDoC criteria. Methods: Using expert review and consensus, we defined four major depression phenotypes based on specific RDoC constructs. Having matched these constructs to individual items from the Hamilton Depression Rating Scale and Quick Inventory of Depressive Symptomatology, we identified subjects meeting criteria for each of these phenotypes from two large clinical trials of patients treated for major depression. In a post hoc analysis, we evaluated the overall treatment response based on the phenotypes: Core Depression (CD), Anxiety (ANX), and Neurovegetative Symptoms of Melancholia (NVSM) and Atypical Depression (NVSAD). Results: The phenotypes were prevalent (range 10.5–52.4{\%}, 50{\%} reduction range 51.9–82.9{\%}) and tracked with overall treatment response. Although the CD phenotype was associated with lower rates of remission in both cohorts, this was mainly driven by baseline symptom severity. However, when controlling for baseline severity, patients with the ANX phenotype had a significantly lower rate of remission. Limitations: The lack of replication between the studies of the phenotypes’ treatment prediction value reflects important variability across studies that may limit generalizability. Conclusion: Further work evaluating biological markers associated with these phenotypes is needed for further RDoC concept development.",
keywords = "Anxiety, Core depression, Major depressive disorder, Neurovegetative symptoms of melancholia and atypical depression, Research domain criteria",
author = "{The Mood Disorders Precision Medicine Consortium (MDPMC)} and Ahmed, {Ahmed T.} and Frye, {Mark A} and Rush, {A. John} and Biernacka, {Joanna M} and Craighead, {W. Edward} and McDonald, {William M.} and Bobo, {William V} and Patricio Riva-Posse and Tye, {Susannah J} and Mayberg, {Helen S.} and Flavin, {Daniel Hall} and Skime, {Michelle K.} and Jenkins, {Greg D.} and Wang, {Liewei M} and Krishnan, {Ranga Rama} and Weinshilboum, {Richard M} and Rima Kaddurah-Daouk and Dunlop, {Boadie W.}",
year = "2018",
month = "10",
day = "1",
doi = "10.1016/j.jad.2018.05.005",
language = "English (US)",
volume = "238",
pages = "1--7",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",

}

TY - JOUR

T1 - Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders

AU - The Mood Disorders Precision Medicine Consortium (MDPMC)

AU - Ahmed, Ahmed T.

AU - Frye, Mark A

AU - Rush, A. John

AU - Biernacka, Joanna M

AU - Craighead, W. Edward

AU - McDonald, William M.

AU - Bobo, William V

AU - Riva-Posse, Patricio

AU - Tye, Susannah J

AU - Mayberg, Helen S.

AU - Flavin, Daniel Hall

AU - Skime, Michelle K.

AU - Jenkins, Greg D.

AU - Wang, Liewei M

AU - Krishnan, Ranga Rama

AU - Weinshilboum, Richard M

AU - Kaddurah-Daouk, Rima

AU - Dunlop, Boadie W.

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Background: Substantial research progress can be achieved if available clinical datasets can be mapped to the National Institute of Mental Health Research-Domain-Criteria (RDoC) constructs. This mapping would allow investigators to both explore more narrowly defined clinical phenotypes and the relationship of these phenotypes to biological markers and clinical outcomes approximating RDoC criteria. Methods: Using expert review and consensus, we defined four major depression phenotypes based on specific RDoC constructs. Having matched these constructs to individual items from the Hamilton Depression Rating Scale and Quick Inventory of Depressive Symptomatology, we identified subjects meeting criteria for each of these phenotypes from two large clinical trials of patients treated for major depression. In a post hoc analysis, we evaluated the overall treatment response based on the phenotypes: Core Depression (CD), Anxiety (ANX), and Neurovegetative Symptoms of Melancholia (NVSM) and Atypical Depression (NVSAD). Results: The phenotypes were prevalent (range 10.5–52.4%, 50% reduction range 51.9–82.9%) and tracked with overall treatment response. Although the CD phenotype was associated with lower rates of remission in both cohorts, this was mainly driven by baseline symptom severity. However, when controlling for baseline severity, patients with the ANX phenotype had a significantly lower rate of remission. Limitations: The lack of replication between the studies of the phenotypes’ treatment prediction value reflects important variability across studies that may limit generalizability. Conclusion: Further work evaluating biological markers associated with these phenotypes is needed for further RDoC concept development.

AB - Background: Substantial research progress can be achieved if available clinical datasets can be mapped to the National Institute of Mental Health Research-Domain-Criteria (RDoC) constructs. This mapping would allow investigators to both explore more narrowly defined clinical phenotypes and the relationship of these phenotypes to biological markers and clinical outcomes approximating RDoC criteria. Methods: Using expert review and consensus, we defined four major depression phenotypes based on specific RDoC constructs. Having matched these constructs to individual items from the Hamilton Depression Rating Scale and Quick Inventory of Depressive Symptomatology, we identified subjects meeting criteria for each of these phenotypes from two large clinical trials of patients treated for major depression. In a post hoc analysis, we evaluated the overall treatment response based on the phenotypes: Core Depression (CD), Anxiety (ANX), and Neurovegetative Symptoms of Melancholia (NVSM) and Atypical Depression (NVSAD). Results: The phenotypes were prevalent (range 10.5–52.4%, 50% reduction range 51.9–82.9%) and tracked with overall treatment response. Although the CD phenotype was associated with lower rates of remission in both cohorts, this was mainly driven by baseline symptom severity. However, when controlling for baseline severity, patients with the ANX phenotype had a significantly lower rate of remission. Limitations: The lack of replication between the studies of the phenotypes’ treatment prediction value reflects important variability across studies that may limit generalizability. Conclusion: Further work evaluating biological markers associated with these phenotypes is needed for further RDoC concept development.

KW - Anxiety

KW - Core depression

KW - Major depressive disorder

KW - Neurovegetative symptoms of melancholia and atypical depression

KW - Research domain criteria

UR - http://www.scopus.com/inward/record.url?scp=85047610520&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047610520&partnerID=8YFLogxK

U2 - 10.1016/j.jad.2018.05.005

DO - 10.1016/j.jad.2018.05.005

M3 - Article

C2 - 29807322

AN - SCOPUS:85047610520

VL - 238

SP - 1

EP - 7

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -