TY - JOUR
T1 - Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome
AU - Eddie Ip, W. K.
AU - Takahashi, Kazue
AU - Moore, Kathryn J.
AU - Stuart, Lynda M.
AU - Ezekowitz, R. Alan B.
PY - 2008/1/21
Y1 - 2008/1/21
N2 - Innate immunity is the first-line defense against pathogens and relies on phagocytes, soluble components, and cell-surface and cytosolic pattern recognition receptors. Despite using hard-wired receptors and signaling pathways, the innate immune response demonstrates surprising specificity to different pathogens. We determined how combinatorial use of innate immune defense mechanisms defines the response. We describe a novel cooperation between a soluble component of the innate immune system, the mannose-binding lectin, and Toll-like receptor 2 that both specifies and amplifies the host response to Staphylococcus aureus. Furthermore, we demonstrate that this cooperation occurs within the phagosome, emphasizing the importance of engulfment in providing the appropriate cellular environment to facilitate the synergy between these defense pathways. JEM
AB - Innate immunity is the first-line defense against pathogens and relies on phagocytes, soluble components, and cell-surface and cytosolic pattern recognition receptors. Despite using hard-wired receptors and signaling pathways, the innate immune response demonstrates surprising specificity to different pathogens. We determined how combinatorial use of innate immune defense mechanisms defines the response. We describe a novel cooperation between a soluble component of the innate immune system, the mannose-binding lectin, and Toll-like receptor 2 that both specifies and amplifies the host response to Staphylococcus aureus. Furthermore, we demonstrate that this cooperation occurs within the phagosome, emphasizing the importance of engulfment in providing the appropriate cellular environment to facilitate the synergy between these defense pathways. JEM
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U2 - 10.1084/jem.20071164
DO - 10.1084/jem.20071164
M3 - Article
C2 - 18180310
AN - SCOPUS:38749153572
SN - 0022-1007
VL - 205
SP - 169
EP - 181
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 1
ER -