Abstract
Drug discovery currently focuses on identifying new druggable targets and drug repurposing. Here, we illustrate a third domain of drug discovery: the dimensionality of treatment regimens. We formulate a new schema called ‘Manifold Medicine’, in which disease states are described by vectorial positions on several body-wide axes. Thus, pathological states are represented by multidimensional ‘vectors’ that traverse the body-wide axes. We then delineate the manifold nature of drug action to provide a strategy for designing manifold drug cocktails by design using state-of-the-art biomedical and technological innovations. Manifold Medicine offers a roadmap for translating knowledge gained from next-generation technologies into individualized clinical practice.
Original language | English (US) |
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Pages (from-to) | 8-16 |
Number of pages | 9 |
Journal | Drug Discovery Today |
Volume | 27 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2022 |
Keywords
- Combinatorial therapeutics
- Individualized medicine
- Manifold medicine
- Systems pharmacology
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery