Manifestations of systemic lupus erythematosus in female patients with polysomy X: Possible roles of chromosome X

Taro Iwamoto, Masanori Fujimoto, Kei Ikeda, Aiko Saku, Sohei Makita, Shunsuke Furuta, Timothy B. Niewold, Hiroshi Nakajima

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Clinical manifestations of systemic lupus erythematosus (SLE) in female patients with polysomy X have been less characterized as compared to those in male patients. Here, we describe a 28-year-old woman with trisomy X (47,XXX) who developed SLE. She had polyarthritis, hemolytic anemia, and was positive for anti-nuclear and anti-dsDNA antibodies. We discuss the common SLE manifestations with female polysomy X and the possible link between the development of SLE and the presence of extra X-chromosomes.

Original languageEnglish (US)
Pages (from-to)1-3
Number of pages3
JournalModern Rheumatology
DOIs
StateAccepted/In press - Jul 11 2016

Keywords

  • Arthritis
  • Female
  • Hemolytic anemia
  • Systemic lupus erythematosus
  • Trisomy X

ASJC Scopus subject areas

  • Rheumatology

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