TY - JOUR
T1 - Managing High-Risk Breast Cancer
AU - Palmieri, Frances M.
AU - Perez, Edith A.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2007/2
Y1 - 2007/2
N2 - Objectives: To identify breast cancer patients at high risk for recurrence. To describe current evidence for clinical management of early and locally advanced breast cancer and integrate this knowledge into nursing practice. Data Sources: Articles, abstracts, and practice guidelines. Conclusion: Recent clinical trials have integrated the biology of breast cancer into individualized systemic therapy. Risk-adjusted treatment is driven by the addition of taxane therapy to systemic therapy, aromatase inhibitors, and trastuzumab into adjuvant therapy strategies. Implications for Nursing Practice: The decision to initiate systemic adjuvant therapy requires knowledge of risk of relapse, integration of evidence from clinical trials, and facilitation of patient decision-making.
AB - Objectives: To identify breast cancer patients at high risk for recurrence. To describe current evidence for clinical management of early and locally advanced breast cancer and integrate this knowledge into nursing practice. Data Sources: Articles, abstracts, and practice guidelines. Conclusion: Recent clinical trials have integrated the biology of breast cancer into individualized systemic therapy. Risk-adjusted treatment is driven by the addition of taxane therapy to systemic therapy, aromatase inhibitors, and trastuzumab into adjuvant therapy strategies. Implications for Nursing Practice: The decision to initiate systemic adjuvant therapy requires knowledge of risk of relapse, integration of evidence from clinical trials, and facilitation of patient decision-making.
KW - Adjuvant trastuzumab trials
KW - HER-2/neu
KW - High-risk breast cancer
KW - Locally advanced breast cancer
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U2 - 10.1016/j.soncn.2006.11.005
DO - 10.1016/j.soncn.2006.11.005
M3 - Article
C2 - 17303514
AN - SCOPUS:33846898499
VL - 23
SP - 29
EP - 36
JO - Seminars in Oncology Nursing
JF - Seminars in Oncology Nursing
SN - 0749-2081
IS - 1
ER -