Management of viral infections in solid organ transplant recipients

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Management of viral infections after transplantation involves antiviral drug therapy (if available) and reduction in immunosuppression, which allows for development of pathogen-specific immunity to the offending virus. Prevention of viral infections is of the utmost importance, and this may be accomplished through vaccination, antiviral strategies and infection control measures. This article discusses the current management of selected viral pathogens that cause clinical illness in solid organ transplant recipients. The benefits and toxicities of antiviral therapies are discussed in the context of prevention and treatment of various viral diseases. The emerging issue of antiviral resistance is emphasized for cytomegalovirus, recurrent hepatitis B and influenza, while the importance of immunominimization is discussed in the management of BK nephropathy and virus-associated malignancies.

Original languageEnglish (US)
Pages (from-to)685-700
Number of pages16
JournalExpert Review of Anti-Infective Therapy
Volume9
Issue number6
DOIs
StatePublished - Jun 2011

Fingerprint

Virus Diseases
Antiviral Agents
Transplants
BK Virus
Infection Control
Hepatitis B
Cytomegalovirus
Immunosuppression
Human Influenza
Immunity
Vaccination
Transplantation
Viruses
Drug Therapy
Transplant Recipients
Therapeutics
Neoplasms

Keywords

  • cytomegalovirus
  • hepatitis B virus
  • hepatitis C virus
  • herpesvirus
  • influenza
  • polyomavirus
  • respiratory viruses
  • transplantation

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Microbiology
  • Virology

Cite this

Management of viral infections in solid organ transplant recipients. / Razonable, Raymund R.

In: Expert Review of Anti-Infective Therapy, Vol. 9, No. 6, 06.2011, p. 685-700.

Research output: Contribution to journalArticle

@article{4e2489cc53cf4d16832296cbf1a0dd98,
title = "Management of viral infections in solid organ transplant recipients",
abstract = "Management of viral infections after transplantation involves antiviral drug therapy (if available) and reduction in immunosuppression, which allows for development of pathogen-specific immunity to the offending virus. Prevention of viral infections is of the utmost importance, and this may be accomplished through vaccination, antiviral strategies and infection control measures. This article discusses the current management of selected viral pathogens that cause clinical illness in solid organ transplant recipients. The benefits and toxicities of antiviral therapies are discussed in the context of prevention and treatment of various viral diseases. The emerging issue of antiviral resistance is emphasized for cytomegalovirus, recurrent hepatitis B and influenza, while the importance of immunominimization is discussed in the management of BK nephropathy and virus-associated malignancies.",
keywords = "cytomegalovirus, hepatitis B virus, hepatitis C virus, herpesvirus, influenza, polyomavirus, respiratory viruses, transplantation",
author = "Razonable, {Raymund R}",
year = "2011",
month = "6",
doi = "10.1586/eri.11.43",
language = "English (US)",
volume = "9",
pages = "685--700",
journal = "Expert Review of Anti-Infective Therapy",
issn = "1478-7210",
publisher = "Expert Reviews Ltd.",
number = "6",

}

TY - JOUR

T1 - Management of viral infections in solid organ transplant recipients

AU - Razonable, Raymund R

PY - 2011/6

Y1 - 2011/6

N2 - Management of viral infections after transplantation involves antiviral drug therapy (if available) and reduction in immunosuppression, which allows for development of pathogen-specific immunity to the offending virus. Prevention of viral infections is of the utmost importance, and this may be accomplished through vaccination, antiviral strategies and infection control measures. This article discusses the current management of selected viral pathogens that cause clinical illness in solid organ transplant recipients. The benefits and toxicities of antiviral therapies are discussed in the context of prevention and treatment of various viral diseases. The emerging issue of antiviral resistance is emphasized for cytomegalovirus, recurrent hepatitis B and influenza, while the importance of immunominimization is discussed in the management of BK nephropathy and virus-associated malignancies.

AB - Management of viral infections after transplantation involves antiviral drug therapy (if available) and reduction in immunosuppression, which allows for development of pathogen-specific immunity to the offending virus. Prevention of viral infections is of the utmost importance, and this may be accomplished through vaccination, antiviral strategies and infection control measures. This article discusses the current management of selected viral pathogens that cause clinical illness in solid organ transplant recipients. The benefits and toxicities of antiviral therapies are discussed in the context of prevention and treatment of various viral diseases. The emerging issue of antiviral resistance is emphasized for cytomegalovirus, recurrent hepatitis B and influenza, while the importance of immunominimization is discussed in the management of BK nephropathy and virus-associated malignancies.

KW - cytomegalovirus

KW - hepatitis B virus

KW - hepatitis C virus

KW - herpesvirus

KW - influenza

KW - polyomavirus

KW - respiratory viruses

KW - transplantation

UR - http://www.scopus.com/inward/record.url?scp=79959704415&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959704415&partnerID=8YFLogxK

U2 - 10.1586/eri.11.43

DO - 10.1586/eri.11.43

M3 - Article

C2 - 21692673

AN - SCOPUS:79959704415

VL - 9

SP - 685

EP - 700

JO - Expert Review of Anti-Infective Therapy

JF - Expert Review of Anti-Infective Therapy

SN - 1478-7210

IS - 6

ER -