TY - JOUR
T1 - Management of necrotizing pancreatitis by repeated operative necrosectomy using a zipper technique
AU - Tsiotos, Gregory G.
AU - Luque-De León, Enrique
AU - Söreide, Jon A.
AU - Bannon, Michael P.
AU - Zietlow, Scott P.
AU - Baerga-Varela, Yvonne
AU - Sarr, Michael G.
PY - 1998/2
Y1 - 1998/2
N2 - METHODS: From 1983 to 1995, 72 patients with necrotizing pancreatitis were treated with a general approach involving planned reoperative necrosectomies and interval abdominal wound closure using a zipper. RESULTS: Hospital mortality was 25%. Multiple organ failure without sepsis caused early mortality in 3 of 4 patients and sepsis caused late mortality in 11 of the remaining 14. The mean number of reoperative necrosectomies/debridements was 2 (0 to 7). Fistulae developed in 25 patients (35%); 64% were treated conservatively. Recurrent intraabdominal abscesses developed in 9 patients (13%) but were drained percutaneously in 5. Hemorrhage required intervention in 13 patients (18%). Prognostic factors included APACHE-II score on admission <13 (P = 0.005), absence of postoperative hemorrhage (P = 0.01), and peripancreatic tissue necrosis alone (P <0.05). CONCLUSIONS: The zipper approach effectively maximizes the necrosectomy and decreases the incidence of recurrent intraabdominal infection requiring reoperation. APACHE-II score ≤13, extensive parenchymal necrosis, and postoperative hemorrhage signify worse outcome.
AB - METHODS: From 1983 to 1995, 72 patients with necrotizing pancreatitis were treated with a general approach involving planned reoperative necrosectomies and interval abdominal wound closure using a zipper. RESULTS: Hospital mortality was 25%. Multiple organ failure without sepsis caused early mortality in 3 of 4 patients and sepsis caused late mortality in 11 of the remaining 14. The mean number of reoperative necrosectomies/debridements was 2 (0 to 7). Fistulae developed in 25 patients (35%); 64% were treated conservatively. Recurrent intraabdominal abscesses developed in 9 patients (13%) but were drained percutaneously in 5. Hemorrhage required intervention in 13 patients (18%). Prognostic factors included APACHE-II score on admission <13 (P = 0.005), absence of postoperative hemorrhage (P = 0.01), and peripancreatic tissue necrosis alone (P <0.05). CONCLUSIONS: The zipper approach effectively maximizes the necrosectomy and decreases the incidence of recurrent intraabdominal infection requiring reoperation. APACHE-II score ≤13, extensive parenchymal necrosis, and postoperative hemorrhage signify worse outcome.
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U2 - 10.1016/S0002-9610(97)00277-8
DO - 10.1016/S0002-9610(97)00277-8
M3 - Article
C2 - 9515522
AN - SCOPUS:0032006696
SN - 0002-9610
VL - 175
SP - 91
EP - 98
JO - American journal of surgery
JF - American journal of surgery
IS - 2
ER -