Management of Myocarditis-Related Cardiomyopathy in Adults

Carsten Tschöpe, Leslie T Jr. Cooper, Guillermo Torre-Amione, Sophie Van Linthout

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Myocarditis is generally a mild and self-limited consequence of systemic infection of cardiotropic viruses. However, patients can develop a temporary or permanent impairment of cardiac function including acute cardiomyopathy with hemodynamic compromise or severe arrhythmias. In this setting, specific causes of inflammation are associated with variable risks of death and transplantation. Recent translational studies suggest that treatments tailored to specific causes of myocarditis may impact clinical outcomes when added to guideline-directed medical care. This review summarizes recent advances in translational research that influence the utility of endomyocardial biopsy for the management of inflammatory cardiomyopathies. Emerging therapies for myocarditis based on these mechanistic hypotheses are entering clinical trials and may add to the benefits of established heart failure treatment.

Original languageEnglish (US)
Pages (from-to)1568-1583
Number of pages16
JournalCirculation research
Volume124
Issue number11
DOIs
StatePublished - May 24 2019

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Keywords

  • biopsy
  • cardiomyopathies
  • heart
  • inflammation
  • myocarditis

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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