TY - JOUR
T1 - Management of multifocal primary cutaneous CD30 + anaplastic large cell lymphoma
AU - Shehan, James M.
AU - Kalaaji, Amer N.
AU - Markovic, Svetomir N.
AU - Ahmed, Iftikhar
PY - 2004/7
Y1 - 2004/7
N2 - Primary cutaneous CD30 + anaplastic large cell lymphoma in adults is rare, but the prognosis is generally excellent. Skin lesions may be localized or, less commonly, multifocal. Although not extensively reported, multifocal primary cutaneous anaplastic large cell lymphoma tends to relapse after systemic chemotherapy and is generally considered more prone to progress to extracutaneous involvement than the localized disease. We report the case of a 21-year-old woman with primary cutaneous CD30 + anaplastic large cell lymphoma manifesting as widespread papules and nodules. Despite remaining localized to the skin, the disease relapsed after multiple chemotherapy regimens and autologous stem-cell transplantation. Treatment with an experimental anti-CD30 monoclonal antibody was successful. Review of this case and similar cases illustrates that traditional combination chemotherapy may not be best. Newer treatments, including anti-CD30 monoclonal antibodies, show promise. However, further study is needed to develop optimal therapeutic strategies.
AB - Primary cutaneous CD30 + anaplastic large cell lymphoma in adults is rare, but the prognosis is generally excellent. Skin lesions may be localized or, less commonly, multifocal. Although not extensively reported, multifocal primary cutaneous anaplastic large cell lymphoma tends to relapse after systemic chemotherapy and is generally considered more prone to progress to extracutaneous involvement than the localized disease. We report the case of a 21-year-old woman with primary cutaneous CD30 + anaplastic large cell lymphoma manifesting as widespread papules and nodules. Despite remaining localized to the skin, the disease relapsed after multiple chemotherapy regimens and autologous stem-cell transplantation. Treatment with an experimental anti-CD30 monoclonal antibody was successful. Review of this case and similar cases illustrates that traditional combination chemotherapy may not be best. Newer treatments, including anti-CD30 monoclonal antibodies, show promise. However, further study is needed to develop optimal therapeutic strategies.
KW - ALCL
KW - ALK
KW - CHOP
KW - anaplastic large cell lymphoma
KW - anaplastic lymphoma kinase
KW - cyclophosphamide, Adriamycin, vincristine, prednisone
UR - http://www.scopus.com/inward/record.url?scp=3142609056&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3142609056&partnerID=8YFLogxK
U2 - 10.1016/j.jaad.2003.12.028
DO - 10.1016/j.jaad.2003.12.028
M3 - Review article
C2 - 15243534
AN - SCOPUS:3142609056
SN - 0190-9622
VL - 51
SP - 103
EP - 110
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 1
ER -