Management of metastatic gastrointestinal stromal tumor by multiple surgical interventions including pancreatoduodenectomy, liver resection and two liver transplants: Worth the effort?

M. Dougherty, H. Bonatti, Rolland Dickson, J. Aranda-Michel, R. Hinder, Justin H Nguyen, J. Steers, Christopher B. Hughes

Research output: Contribution to journalArticle

Abstract

Background: Gastrointestinal stromal tumor (GIST) is a rare malignant disease which originates from the pacemaker cells of the gastrointestinal tract and in the case of metastatic spread usually has a poor prognosis. Methods: We report a case of a woman who underwent multiple surgical procedures including a pancreatic resection and two liver transplants and in addition received Gleevec, somatostatin and the new experimental compound Sunitinib. Results: With this intensive approach she survived more than 12 years after being first diagnosed with GIST. Conclusions: In selected cases patients with metastatic GIST may benefit from such an aggressive approach.

Original languageEnglish (US)
Pages (from-to)189-191
Number of pages3
JournalEuropean Surgery - Acta Chirurgica Austriaca
Volume39
Issue number3
DOIs
StatePublished - 2007

Fingerprint

Gastrointestinal Stromal Tumors
Pancreaticoduodenectomy
Transplants
Liver
Rare Diseases
Somatostatin
Gastrointestinal Tract

Keywords

  • GIST
  • Gleevec
  • Liver transplant

ASJC Scopus subject areas

  • Surgery

Cite this

Management of metastatic gastrointestinal stromal tumor by multiple surgical interventions including pancreatoduodenectomy, liver resection and two liver transplants : Worth the effort? / Dougherty, M.; Bonatti, H.; Dickson, Rolland; Aranda-Michel, J.; Hinder, R.; Nguyen, Justin H; Steers, J.; Hughes, Christopher B.

In: European Surgery - Acta Chirurgica Austriaca, Vol. 39, No. 3, 2007, p. 189-191.

Research output: Contribution to journalArticle

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AU - Nguyen, Justin H

AU - Steers, J.

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AB - Background: Gastrointestinal stromal tumor (GIST) is a rare malignant disease which originates from the pacemaker cells of the gastrointestinal tract and in the case of metastatic spread usually has a poor prognosis. Methods: We report a case of a woman who underwent multiple surgical procedures including a pancreatic resection and two liver transplants and in addition received Gleevec, somatostatin and the new experimental compound Sunitinib. Results: With this intensive approach she survived more than 12 years after being first diagnosed with GIST. Conclusions: In selected cases patients with metastatic GIST may benefit from such an aggressive approach.

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