Management of hot flashes in breast cancer patients

Amanda R. Moraska, Jason M. Moraska, Kostandinos Sideras, Charles Lawrence Loprinzi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Hot flashes, commonly experienced by women during menopause, can significantly and negatively impact quality of life. Women receiving hormone therapy for breast cancer are particularly prone to developing these symptoms and hot flashes in this patient population can be more challenging to manage. Although hormonal agents are the most effective treatment options, they are avoided in these patients due to concerns over increased risk of breast cancer recurrence. This issue has prompted research into many nonhormonal therapies in randomized, placebo-controlled trials. Paroxetine, venlafaxine, desvenlafaxine, fluoxetine, citalopram, gabapentin, and pregabalin are among those shown to have some efficacy. There have also been several studies of nonpharmacologic therapies that have demonstrated varying levels of success. In addition, special consideration should be given to interactions of several commonly used medications with the metabolism of tamoxifen. This article presents a discussion of the current literature, through December 2009, primarily related to nonhormonal therapeutic options for hot flashes, including considerations for patients receiving tamoxifen for the prevention or the treatment of breast cancer.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalEuropean journal of Clinical and Medical Oncology
Volume4
Issue number1
StatePublished - 2012

Fingerprint

Hot Flashes
Breast Neoplasms
Tamoxifen
Therapeutics
Paroxetine
Citalopram
Fluoxetine
Menopause
Randomized Controlled Trials
Placebos
Quality of Life
Hormones
Recurrence
Research
Population

Keywords

  • Breast cancer
  • CYP2D6
  • Hot flashes
  • Pharmacogenomics
  • Tamoxifen

ASJC Scopus subject areas

  • Oncology

Cite this

Management of hot flashes in breast cancer patients. / Moraska, Amanda R.; Moraska, Jason M.; Sideras, Kostandinos; Loprinzi, Charles Lawrence.

In: European journal of Clinical and Medical Oncology, Vol. 4, No. 1, 2012, p. 1-9.

Research output: Contribution to journalArticle

Moraska, Amanda R. ; Moraska, Jason M. ; Sideras, Kostandinos ; Loprinzi, Charles Lawrence. / Management of hot flashes in breast cancer patients. In: European journal of Clinical and Medical Oncology. 2012 ; Vol. 4, No. 1. pp. 1-9.
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