HCV-related cirrhosis is still a valid indication for LT, despite the frequency of recurrence. As this segment of the LT-recipient population grows, the transplantation hepatologist needs to consider the challenge of preventing aggressive recurrence and considering the value of retransplantation in this patient group. Current treatment options for HCV offer limited chance of long-term success. There is ample room for investigation into the most beneficial regimen and duration of treatment, the time at which one should start, and how all the factors over which the clinician and patient have control will be manipulated to achieve the highest possible disease- and symptom-free survival.
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