Management of germ cell tumors

Manish Kohli, Ben Y. Zhang, Brian Costello

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Germ cell tumors typically present in younger age populations and are known to be extremely sensitive to chemotherapy and radiation. As a result of this, remarkable progress has been achieved for offering a high degree of curative outcomes for these tumor types using a stepwise, stage-specific integration of surgery, chemotherapy, and radiation. A common theme in the treatment paradigm is to offer high cure rates without compromising on fertility in this typically young population of patients. This chapter will summarize the management of germ cell tumors using testicular germ cell tumors as the prototype example since it has been studied extensively. Principles of management of malignant ovarian germ cell tumors are currently based on treatments that have evolved from the study of testicular cancer and also offer a high rate of cure.

Original languageEnglish (US)
Title of host publicationPathology and Biology of Human Germ Cell Tumors
PublisherSpringer Berlin Heidelberg
Pages181-194
Number of pages14
ISBN (Electronic)9783662537756
ISBN (Print)9783662537732
DOIs
StatePublished - Jan 1 2017

Fingerprint

Germ Cell and Embryonal Neoplasms
Radiation
Drug Therapy
Testicular Neoplasms
Population
Fertility
Therapeutics
Neoplasms

Keywords

  • Germ cell tumor
  • Non-seminoma
  • Ovarian
  • Seminoma
  • Treatment

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kohli, M., Zhang, B. Y., & Costello, B. (2017). Management of germ cell tumors. In Pathology and Biology of Human Germ Cell Tumors (pp. 181-194). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-662-53775-6_5

Management of germ cell tumors. / Kohli, Manish; Zhang, Ben Y.; Costello, Brian.

Pathology and Biology of Human Germ Cell Tumors. Springer Berlin Heidelberg, 2017. p. 181-194.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kohli, M, Zhang, BY & Costello, B 2017, Management of germ cell tumors. in Pathology and Biology of Human Germ Cell Tumors. Springer Berlin Heidelberg, pp. 181-194. https://doi.org/10.1007/978-3-662-53775-6_5
Kohli M, Zhang BY, Costello B. Management of germ cell tumors. In Pathology and Biology of Human Germ Cell Tumors. Springer Berlin Heidelberg. 2017. p. 181-194 https://doi.org/10.1007/978-3-662-53775-6_5
Kohli, Manish ; Zhang, Ben Y. ; Costello, Brian. / Management of germ cell tumors. Pathology and Biology of Human Germ Cell Tumors. Springer Berlin Heidelberg, 2017. pp. 181-194
@inbook{f946d4ee2dbb4d48a3b80e2dfdd134fa,
title = "Management of germ cell tumors",
abstract = "Germ cell tumors typically present in younger age populations and are known to be extremely sensitive to chemotherapy and radiation. As a result of this, remarkable progress has been achieved for offering a high degree of curative outcomes for these tumor types using a stepwise, stage-specific integration of surgery, chemotherapy, and radiation. A common theme in the treatment paradigm is to offer high cure rates without compromising on fertility in this typically young population of patients. This chapter will summarize the management of germ cell tumors using testicular germ cell tumors as the prototype example since it has been studied extensively. Principles of management of malignant ovarian germ cell tumors are currently based on treatments that have evolved from the study of testicular cancer and also offer a high rate of cure.",
keywords = "Germ cell tumor, Non-seminoma, Ovarian, Seminoma, Treatment",
author = "Manish Kohli and Zhang, {Ben Y.} and Brian Costello",
year = "2017",
month = "1",
day = "1",
doi = "10.1007/978-3-662-53775-6_5",
language = "English (US)",
isbn = "9783662537732",
pages = "181--194",
booktitle = "Pathology and Biology of Human Germ Cell Tumors",
publisher = "Springer Berlin Heidelberg",

}

TY - CHAP

T1 - Management of germ cell tumors

AU - Kohli, Manish

AU - Zhang, Ben Y.

AU - Costello, Brian

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Germ cell tumors typically present in younger age populations and are known to be extremely sensitive to chemotherapy and radiation. As a result of this, remarkable progress has been achieved for offering a high degree of curative outcomes for these tumor types using a stepwise, stage-specific integration of surgery, chemotherapy, and radiation. A common theme in the treatment paradigm is to offer high cure rates without compromising on fertility in this typically young population of patients. This chapter will summarize the management of germ cell tumors using testicular germ cell tumors as the prototype example since it has been studied extensively. Principles of management of malignant ovarian germ cell tumors are currently based on treatments that have evolved from the study of testicular cancer and also offer a high rate of cure.

AB - Germ cell tumors typically present in younger age populations and are known to be extremely sensitive to chemotherapy and radiation. As a result of this, remarkable progress has been achieved for offering a high degree of curative outcomes for these tumor types using a stepwise, stage-specific integration of surgery, chemotherapy, and radiation. A common theme in the treatment paradigm is to offer high cure rates without compromising on fertility in this typically young population of patients. This chapter will summarize the management of germ cell tumors using testicular germ cell tumors as the prototype example since it has been studied extensively. Principles of management of malignant ovarian germ cell tumors are currently based on treatments that have evolved from the study of testicular cancer and also offer a high rate of cure.

KW - Germ cell tumor

KW - Non-seminoma

KW - Ovarian

KW - Seminoma

KW - Treatment

UR - http://www.scopus.com/inward/record.url?scp=85034614901&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85034614901&partnerID=8YFLogxK

U2 - 10.1007/978-3-662-53775-6_5

DO - 10.1007/978-3-662-53775-6_5

M3 - Chapter

AN - SCOPUS:85034614901

SN - 9783662537732

SP - 181

EP - 194

BT - Pathology and Biology of Human Germ Cell Tumors

PB - Springer Berlin Heidelberg

ER -