Management of eosinophilic esophagitis and celiac disease

Rok Seon Choung, Jeffrey A. Alexander, David A Katzka, Joseph A Murray

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Eosinophilic esophagitis (EoE) and celiac disease (CeD) are chronic immune mediated gastrointestinal disorders characterized by mucosal inflammation, both of which are related to food antigens, but with differences in clinical and histopathological features. When untreated, both diseases lead to destruction of the epithelium. While a strict gluten-free diet is the only effective therapy for CeD, several therapeutic options, such as proton pump inhibitors, topical steroids and diet elimination therapy are available for EoE. For EoE patients, all can be efficacious in achieving remission, but the looming question is whether all patients should be on maintenance therapy. New biologic therapies are being studied under study in both diseases, but none are ready for clinical use.

Original languageEnglish (US)
Pages (from-to)118-125
Number of pages8
JournalCurrent Opinion in Pharmacology
Volume37
DOIs
StatePublished - Dec 1 2017

Fingerprint

Eosinophilic Esophagitis
Celiac Disease
Diet Therapy
Gluten-Free Diet
Biological Therapy
Proton Pump Inhibitors
Therapeutics
Epithelium
Steroids
Inflammation
Antigens
Food

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Management of eosinophilic esophagitis and celiac disease. / Choung, Rok Seon; Alexander, Jeffrey A.; Katzka, David A; Murray, Joseph A.

In: Current Opinion in Pharmacology, Vol. 37, 01.12.2017, p. 118-125.

Research output: Contribution to journalReview article

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