Management of cold haemolytic syndrome

Research output: Contribution to journalReview article

52 Citations (Scopus)

Abstract

Most haemolytic disease is mediated by immunoglobulin G (IgG) antibodies and leads to red blood cell destruction outside of the circulatory system. However, rare syndromes, such as paroxysmal cold haemoglobinuria, show IgG antibodies causing intravascular destruction. Haemolysis may also occur because of immunoglobulin M antibodies. Historically, these antibodies have been termed 'cold agglutinins' because they cause agglutination of red blood cells at 3°C. Cold agglutinin haemolytic anaemia has been associated with a number of autoimmune and lymphoproliferative disorders, and its management differs substantially from warm antibody-mediated haemolytic anaemia. This review of cold haemolytic syndromes describes new therapies and clinical strategies to determine a correct diagnosis.

Original languageEnglish (US)
Pages (from-to)422-429
Number of pages8
JournalBritish Journal of Haematology
Volume138
Issue number4
DOIs
StatePublished - Aug 1 2007

Fingerprint

Antibodies
Hemolytic Anemia
Immunoglobulin G
Erythrocytes
Paroxysmal Hemoglobinuria
Lymphoproliferative Disorders
Agglutination
Cardiovascular System
Hemolysis
Immunoglobulin M
cold agglutinins
Therapeutics

Keywords

  • Cold agglutinin
  • IgM monoclonal protein
  • MGUS
  • Paroxysmal cold haemoglobinuria
  • Waldenström macroglobulinaemia

ASJC Scopus subject areas

  • Hematology

Cite this

Management of cold haemolytic syndrome. / Gertz, Morie.

In: British Journal of Haematology, Vol. 138, No. 4, 01.08.2007, p. 422-429.

Research output: Contribution to journalReview article

@article{d2a6833c14d349d4b9150457dc5897f5,
title = "Management of cold haemolytic syndrome",
abstract = "Most haemolytic disease is mediated by immunoglobulin G (IgG) antibodies and leads to red blood cell destruction outside of the circulatory system. However, rare syndromes, such as paroxysmal cold haemoglobinuria, show IgG antibodies causing intravascular destruction. Haemolysis may also occur because of immunoglobulin M antibodies. Historically, these antibodies have been termed 'cold agglutinins' because they cause agglutination of red blood cells at 3°C. Cold agglutinin haemolytic anaemia has been associated with a number of autoimmune and lymphoproliferative disorders, and its management differs substantially from warm antibody-mediated haemolytic anaemia. This review of cold haemolytic syndromes describes new therapies and clinical strategies to determine a correct diagnosis.",
keywords = "Cold agglutinin, IgM monoclonal protein, MGUS, Paroxysmal cold haemoglobinuria, Waldenstr{\"o}m macroglobulinaemia",
author = "Morie Gertz",
year = "2007",
month = "8",
day = "1",
doi = "10.1111/j.1365-2141.2007.06664.x",
language = "English (US)",
volume = "138",
pages = "422--429",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Management of cold haemolytic syndrome

AU - Gertz, Morie

PY - 2007/8/1

Y1 - 2007/8/1

N2 - Most haemolytic disease is mediated by immunoglobulin G (IgG) antibodies and leads to red blood cell destruction outside of the circulatory system. However, rare syndromes, such as paroxysmal cold haemoglobinuria, show IgG antibodies causing intravascular destruction. Haemolysis may also occur because of immunoglobulin M antibodies. Historically, these antibodies have been termed 'cold agglutinins' because they cause agglutination of red blood cells at 3°C. Cold agglutinin haemolytic anaemia has been associated with a number of autoimmune and lymphoproliferative disorders, and its management differs substantially from warm antibody-mediated haemolytic anaemia. This review of cold haemolytic syndromes describes new therapies and clinical strategies to determine a correct diagnosis.

AB - Most haemolytic disease is mediated by immunoglobulin G (IgG) antibodies and leads to red blood cell destruction outside of the circulatory system. However, rare syndromes, such as paroxysmal cold haemoglobinuria, show IgG antibodies causing intravascular destruction. Haemolysis may also occur because of immunoglobulin M antibodies. Historically, these antibodies have been termed 'cold agglutinins' because they cause agglutination of red blood cells at 3°C. Cold agglutinin haemolytic anaemia has been associated with a number of autoimmune and lymphoproliferative disorders, and its management differs substantially from warm antibody-mediated haemolytic anaemia. This review of cold haemolytic syndromes describes new therapies and clinical strategies to determine a correct diagnosis.

KW - Cold agglutinin

KW - IgM monoclonal protein

KW - MGUS

KW - Paroxysmal cold haemoglobinuria

KW - Waldenström macroglobulinaemia

UR - http://www.scopus.com/inward/record.url?scp=34447299392&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34447299392&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2141.2007.06664.x

DO - 10.1111/j.1365-2141.2007.06664.x

M3 - Review article

VL - 138

SP - 422

EP - 429

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 4

ER -