Management of chemotherapy-induced alopecia (CIA): A comprehensive review and future directions

Emaan Haque; Mohamad S. Alabdaljabar; Kathryn J. Ruddy; Tufia C. Haddad; Carrie A. Thompson; Julia S. Lehman; Shahrukh K. Hashmi

doi:10.1016/j.critrevonc.2020.103093

Management of chemotherapy-induced alopecia (CIA): A comprehensive review and future directions

Emaan Haque, Mohamad S. Alabdaljabar, Kathryn J. Ruddy, Tufia C. Haddad, Carrie A. Thompson, Julia S. Lehman, Shahrukh K. Hashmi

Research output: Contribution to journal › Review article › peer-review

Abstract

Objectives: To review and summarize the available literature on the management of chemotherapy-induced alopecia (CIA) including complementary and alternative medicine (CAM), and to present CIA's effect on quality of life (QoL). Methods: Nine databases were searched for CIA-related keywords, including the effect on QoL, and management options. Among 1019 articles found, 54 articles focusing on treatment/prevention or QoL were retrieved. References of selected articles were also checked manually. Results: CIA was found to negatively affect QoL and body image, regardless of head covering status (i.e., for cultural or religious reasons). Most studies related to treatment/prevention of CIA reported on the use of scalp-cooling. The efficacy of CAM treatments was found to be questionable. Conclusion: A high incidence rate of CIA exists with certain chemotherapies, and it significantly impairs QoL. Preventive and treatment strategies are incompletely effective. Additional literature is needed to explore potential preventive or therapeutic options for CIA.

Original language	English (US)
Article number	103093
Journal	Critical Reviews in Oncology/Hematology
Volume	156
DOIs	https://doi.org/10.1016/j.critrevonc.2020.103093
State	Published - Dec 2020

Keywords

Alopecia
Chemotherapy
Hair-loss

ASJC Scopus subject areas

Hematology
Oncology

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10.1016/j.critrevonc.2020.103093

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title = "Management of chemotherapy-induced alopecia (CIA): A comprehensive review and future directions",

abstract = "Objectives: To review and summarize the available literature on the management of chemotherapy-induced alopecia (CIA) including complementary and alternative medicine (CAM), and to present CIA's effect on quality of life (QoL). Methods: Nine databases were searched for CIA-related keywords, including the effect on QoL, and management options. Among 1019 articles found, 54 articles focusing on treatment/prevention or QoL were retrieved. References of selected articles were also checked manually. Results: CIA was found to negatively affect QoL and body image, regardless of head covering status (i.e., for cultural or religious reasons). Most studies related to treatment/prevention of CIA reported on the use of scalp-cooling. The efficacy of CAM treatments was found to be questionable. Conclusion: A high incidence rate of CIA exists with certain chemotherapies, and it significantly impairs QoL. Preventive and treatment strategies are incompletely effective. Additional literature is needed to explore potential preventive or therapeutic options for CIA.",

keywords = "Alopecia, Chemotherapy, Hair-loss",

author = "Emaan Haque and Alabdaljabar, {Mohamad S.} and Ruddy, {Kathryn J.} and Haddad, {Tufia C.} and Thompson, {Carrie A.} and Lehman, {Julia S.} and Hashmi, {Shahrukh K.}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",

year = "2020",

month = dec,

doi = "10.1016/j.critrevonc.2020.103093",

language = "English (US)",

volume = "156",

journal = "Critical Reviews in Oncology/Hematology",

issn = "1040-8428",

publisher = "Elsevier Ireland Ltd",

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TY - JOUR

T1 - Management of chemotherapy-induced alopecia (CIA)

T2 - A comprehensive review and future directions

AU - Haque, Emaan

AU - Alabdaljabar, Mohamad S.

AU - Ruddy, Kathryn J.

AU - Haddad, Tufia C.

AU - Thompson, Carrie A.

AU - Lehman, Julia S.

AU - Hashmi, Shahrukh K.

PY - 2020/12

Y1 - 2020/12

N2 - Objectives: To review and summarize the available literature on the management of chemotherapy-induced alopecia (CIA) including complementary and alternative medicine (CAM), and to present CIA's effect on quality of life (QoL). Methods: Nine databases were searched for CIA-related keywords, including the effect on QoL, and management options. Among 1019 articles found, 54 articles focusing on treatment/prevention or QoL were retrieved. References of selected articles were also checked manually. Results: CIA was found to negatively affect QoL and body image, regardless of head covering status (i.e., for cultural or religious reasons). Most studies related to treatment/prevention of CIA reported on the use of scalp-cooling. The efficacy of CAM treatments was found to be questionable. Conclusion: A high incidence rate of CIA exists with certain chemotherapies, and it significantly impairs QoL. Preventive and treatment strategies are incompletely effective. Additional literature is needed to explore potential preventive or therapeutic options for CIA.

AB - Objectives: To review and summarize the available literature on the management of chemotherapy-induced alopecia (CIA) including complementary and alternative medicine (CAM), and to present CIA's effect on quality of life (QoL). Methods: Nine databases were searched for CIA-related keywords, including the effect on QoL, and management options. Among 1019 articles found, 54 articles focusing on treatment/prevention or QoL were retrieved. References of selected articles were also checked manually. Results: CIA was found to negatively affect QoL and body image, regardless of head covering status (i.e., for cultural or religious reasons). Most studies related to treatment/prevention of CIA reported on the use of scalp-cooling. The efficacy of CAM treatments was found to be questionable. Conclusion: A high incidence rate of CIA exists with certain chemotherapies, and it significantly impairs QoL. Preventive and treatment strategies are incompletely effective. Additional literature is needed to explore potential preventive or therapeutic options for CIA.

KW - Alopecia

KW - Chemotherapy

KW - Hair-loss

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DO - 10.1016/j.critrevonc.2020.103093

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JO - Critical Reviews in Oncology/Hematology

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Management of chemotherapy-induced alopecia (CIA): A comprehensive review and future directions

Abstract

Keywords

ASJC Scopus subject areas

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