Management of Antiplatelet Agents and Anticoagulants in Patients with Gastrointestinal Bleeding

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6 Citations (Scopus)

Abstract

Antithrombotic drugs (anticoagulants, aspirin, and other antiplatelet agents) are used to treat cardiovascular disease and to prevent secondary thromboembolic events. These drugs are independently associated with an increased risk of gastrointestinal bleeding (GIB), and, when prescribed in combination, further increase the risk of adverse bleeding events. Clinical evidence to inform the choice of endoscopic hemostatic procedure, safe temporary drug cessation, and use of reversal agents is reviewed to optimize management following clinically significant GIB.

Original languageEnglish (US)
Pages (from-to)449-462
Number of pages14
JournalGastrointestinal Endoscopy Clinics of North America
Volume25
Issue number3
DOIs
StatePublished - Jul 1 2015

Fingerprint

Platelet Aggregation Inhibitors
Anticoagulants
Hemorrhage
Hemostatics
Pharmaceutical Preparations
Aspirin
Cardiovascular Diseases

Keywords

  • Adverse effects
  • Gastrointestinal hemorrhage
  • Lower gastrointestinal bleeding
  • Novel oral anticoagulant
  • Thienopyridine
  • Upper gastrointestinal bleeding

ASJC Scopus subject areas

  • Gastroenterology

Cite this

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abstract = "Antithrombotic drugs (anticoagulants, aspirin, and other antiplatelet agents) are used to treat cardiovascular disease and to prevent secondary thromboembolic events. These drugs are independently associated with an increased risk of gastrointestinal bleeding (GIB), and, when prescribed in combination, further increase the risk of adverse bleeding events. Clinical evidence to inform the choice of endoscopic hemostatic procedure, safe temporary drug cessation, and use of reversal agents is reviewed to optimize management following clinically significant GIB.",
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AB - Antithrombotic drugs (anticoagulants, aspirin, and other antiplatelet agents) are used to treat cardiovascular disease and to prevent secondary thromboembolic events. These drugs are independently associated with an increased risk of gastrointestinal bleeding (GIB), and, when prescribed in combination, further increase the risk of adverse bleeding events. Clinical evidence to inform the choice of endoscopic hemostatic procedure, safe temporary drug cessation, and use of reversal agents is reviewed to optimize management following clinically significant GIB.

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