Mammographic density: Potential as a risk factor and surrogate marker in the clinical setting

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Mammographic breast density reflects the relative proportions of fat, connective, and epithelial tissue on the mammogram. Studied for over 30 years, breast density continues to be one of the strongest risk factors for all types of breast cancer. Recent evidence suggests breast density may be a useful surrogate marker for response to endocrine therapies and potentially, a marker of local recurrence as well. High density is also prevalent in the population, with 32 % of women estimated to have breasts over 50 % dense. Because of the importance and prevalence of breast density, state and federal governments have proposed or passed legislation to mandate physicians to provide information on a woman's breast density, especially if increased. We review the evidence and clinical utility for mammographic breast density in context of breast cancer risk, outcomes, and response to therapy. Further, we describe the implications of high density for screening, and include a discussion of potential supplemental screening strategies for women with high density.

Original languageEnglish (US)
Pages (from-to)183-193
Number of pages11
JournalCurrent Breast Cancer Reports
Volume5
Issue number3
DOIs
StatePublished - Sep 2013

Fingerprint

Biomarkers
Breast Neoplasms
State Government
Federal Government
Legislation
Connective Tissue
Breast Density
Breast
Epithelium
Fats
Physicians
Recurrence
Therapeutics
Population

Keywords

  • BI-RADS
  • Breast cancer
  • Breast density
  • Dense breasts
  • Risk factor
  • Risk prediction
  • Supplemental screening

ASJC Scopus subject areas

  • Oncology

Cite this

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abstract = "Mammographic breast density reflects the relative proportions of fat, connective, and epithelial tissue on the mammogram. Studied for over 30 years, breast density continues to be one of the strongest risk factors for all types of breast cancer. Recent evidence suggests breast density may be a useful surrogate marker for response to endocrine therapies and potentially, a marker of local recurrence as well. High density is also prevalent in the population, with 32 {\%} of women estimated to have breasts over 50 {\%} dense. Because of the importance and prevalence of breast density, state and federal governments have proposed or passed legislation to mandate physicians to provide information on a woman's breast density, especially if increased. We review the evidence and clinical utility for mammographic breast density in context of breast cancer risk, outcomes, and response to therapy. Further, we describe the implications of high density for screening, and include a discussion of potential supplemental screening strategies for women with high density.",
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AU - Brandt, Kathleen R

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N2 - Mammographic breast density reflects the relative proportions of fat, connective, and epithelial tissue on the mammogram. Studied for over 30 years, breast density continues to be one of the strongest risk factors for all types of breast cancer. Recent evidence suggests breast density may be a useful surrogate marker for response to endocrine therapies and potentially, a marker of local recurrence as well. High density is also prevalent in the population, with 32 % of women estimated to have breasts over 50 % dense. Because of the importance and prevalence of breast density, state and federal governments have proposed or passed legislation to mandate physicians to provide information on a woman's breast density, especially if increased. We review the evidence and clinical utility for mammographic breast density in context of breast cancer risk, outcomes, and response to therapy. Further, we describe the implications of high density for screening, and include a discussion of potential supplemental screening strategies for women with high density.

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