Mammary involution and breast cancer risk: Transgenic models and clinical studies

Derek C. Radisky, Lynn C. Hartmann

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

Postlactational involution is the process following weaning during which the mammary gland undergoes massive cell death and tissue remodeling as it returns to the pre-pregnant state. Lobular involution is the process by which the breast epithelial tissue is gradually lost with aging of the mammary gland. While postlactational involution and lobular involution are distinct processes, recent studies have indicated that both are related to breast cancer development. Experiments using a variety of rodent models, as well as observations in human populations, suggest that deregulation of postlactational involution may act to facilitate tumor formation. By contrast, new human studies show that completion of lobular involution protects against subsequent breast cancer incidence.

Original languageEnglish (US)
Pages (from-to)181-191
Number of pages11
JournalJournal of mammary gland biology and neoplasia
Volume14
Issue number2
DOIs
StatePublished - 2009

Keywords

  • Breast cancer risk
  • Clinical studies
  • Lobular involution
  • Postlactational involution
  • Transgenic models

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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