Malignant Uveal Schwannoma With Peripheral Nerve Extension in a 12-Week-Old Color-Dilute Labrador Retriever

F. D. Duke, Leandro B.C. Teixeira, L. E. Galle, N. Green, R. R. Dubielzig

Research output: Contribution to journalArticlepeer-review

Abstract

The formalin-fixed, amber-colored right globe from a 12-week-old female silver Labrador Retriever dog was submitted to the Comparative Ocular Pathology Laboratory of Wisconsin for light microscopic evaluation. The clinical history described a collapsed anterior chamber and multifocal nodular lesions in the peripheral iris. Histologically, immunohistochemically, and ultrastructurally, the uveal mass was consistent with a malignant schwannoma; there was extension along peripheral nerves within the sclera. The signalment and behavior of the neoplasm distinguish it from the uveal schwannoma of blue-eyed dogs and bear some resemblance to the ocular lesions in human neurofibromatosis. The dilute color mutation may contribute to the cause. Six weeks later, the dog did not develop any additional masses.

Original languageEnglish (US)
Pages (from-to)181-185
Number of pages5
JournalVeterinary Pathology
Volume52
Issue number1
DOIs
StatePublished - Jan 29 2015

Keywords

  • canine
  • color dilute
  • eye
  • juvenile
  • neurofibromatosis
  • schwannoma
  • uveal schwannoma of blue-eyed dogs

ASJC Scopus subject areas

  • veterinary(all)

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