Malignant uveal melanoma and similar lesions studied by computed tomography

M. F. Mafee, G. A. Peyman, M. A. McKusick

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Forty-four patients with intraocular disease were studied by computed tomography (CT); in 19 cases malignant uveal melanoma was considered the likely diagnosis. CT proved to be accurate in determining the location and size of uveal melanomas, demonstrating scleral invasion, and differentiating melanoma from choroidal detachment or angioma, toxocariasis, and senile macular degeneration. Astrocytic retinal hamartoma and medulloepithelioma could not be distinguished from melanoma with CT. On CT, uveal melanomas appeared as hyperdense lesions with slight to moderate contrast enhancement. Tumors thinner than 2 mm could not be seen. Using dynamic CT, we noted moderate peak amplitude, normal or delayed tissue transit time, and persistently elevated washout phase (down-slope), indicating increased permeability as the result of an impaired tumor blood barrier. Histological types of uveal melanoma could not be differentiated on the basis of circulatory patterns. Dynamic CT may be useful in distinguishing uveal melanoma from choroidal hemangioma or hematoma.

Original languageEnglish (US)
Pages (from-to)403-408
Number of pages6
JournalRadiology
Volume156
Issue number2
StatePublished - 1985
Externally publishedYes

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Melanoma
Tomography
Hemangioma
Toxocariasis
Primitive Neuroectodermal Tumors
Hamartoma
Hematoma
Uveal melanoma
Permeability
Neoplasms

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Mafee, M. F., Peyman, G. A., & McKusick, M. A. (1985). Malignant uveal melanoma and similar lesions studied by computed tomography. Radiology, 156(2), 403-408.

Malignant uveal melanoma and similar lesions studied by computed tomography. / Mafee, M. F.; Peyman, G. A.; McKusick, M. A.

In: Radiology, Vol. 156, No. 2, 1985, p. 403-408.

Research output: Contribution to journalArticle

Mafee, MF, Peyman, GA & McKusick, MA 1985, 'Malignant uveal melanoma and similar lesions studied by computed tomography', Radiology, vol. 156, no. 2, pp. 403-408.
Mafee MF, Peyman GA, McKusick MA. Malignant uveal melanoma and similar lesions studied by computed tomography. Radiology. 1985;156(2):403-408.
Mafee, M. F. ; Peyman, G. A. ; McKusick, M. A. / Malignant uveal melanoma and similar lesions studied by computed tomography. In: Radiology. 1985 ; Vol. 156, No. 2. pp. 403-408.
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