TY - JOUR
T1 - Malignant uveal melanoma and similar lesions studied by computed tomography
AU - Mafee, M. F.
AU - Peyman, G. A.
AU - McKusick, M. A.
PY - 1985
Y1 - 1985
N2 - Forty-four patients with intraocular disease were studied by computed tomography (CT); in 19 cases malignant uveal melanoma was considered the likely diagnosis. CT proved to be accurate in determining the location and size of uveal melanomas, demonstrating scleral invasion, and differentiating melanoma from choroidal detachment or angioma, toxocariasis, and senile macular degeneration. Astrocytic retinal hamartoma and medulloepithelioma could not be distinguished from melanoma with CT. On CT, uveal melanomas appeared as hyperdense lesions with slight to moderate contrast enhancement. Tumors thinner than 2 mm could not be seen. Using dynamic CT, we noted moderate peak amplitude, normal or delayed tissue transit time, and persistently elevated washout phase (down-slope), indicating increased permeability as the result of an impaired tumor blood barrier. Histological types of uveal melanoma could not be differentiated on the basis of circulatory patterns. Dynamic CT may be useful in distinguishing uveal melanoma from choroidal hemangioma or hematoma.
AB - Forty-four patients with intraocular disease were studied by computed tomography (CT); in 19 cases malignant uveal melanoma was considered the likely diagnosis. CT proved to be accurate in determining the location and size of uveal melanomas, demonstrating scleral invasion, and differentiating melanoma from choroidal detachment or angioma, toxocariasis, and senile macular degeneration. Astrocytic retinal hamartoma and medulloepithelioma could not be distinguished from melanoma with CT. On CT, uveal melanomas appeared as hyperdense lesions with slight to moderate contrast enhancement. Tumors thinner than 2 mm could not be seen. Using dynamic CT, we noted moderate peak amplitude, normal or delayed tissue transit time, and persistently elevated washout phase (down-slope), indicating increased permeability as the result of an impaired tumor blood barrier. Histological types of uveal melanoma could not be differentiated on the basis of circulatory patterns. Dynamic CT may be useful in distinguishing uveal melanoma from choroidal hemangioma or hematoma.
UR - http://www.scopus.com/inward/record.url?scp=0021826431&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021826431&partnerID=8YFLogxK
U2 - 10.1148/radiology.156.2.4011902
DO - 10.1148/radiology.156.2.4011902
M3 - Article
C2 - 4011902
AN - SCOPUS:0021826431
SN - 0033-8419
VL - 156
SP - 403
EP - 408
JO - Radiology
JF - Radiology
IS - 2
ER -