Malignant, predominantly lymphocytic thymoma with central and peripheral nervous system metastases

M. R. Wick, W. C. Nichols, J. N. Ingle, J. E. Bruckman, H. Okazaki

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Histologic features of an invasive mediastinal tumor found in a 25-year-old woman fulfilled the accepted criteria for diagnosis of predominantly lymphocytic thymoma. Histochemical and cell marker studies indicated that the neoplasm contained a preponderance of T lymphocytes. After surgical debulking of the mass, aggressive radiotherapy and chemotherapy eradicated all evidence of thoracic disease. However, 6 months after the initial diagnosis, rapid development of cranial nerve and brainstem metastases - without detectable recurrent disease elsewhere - resulted in the patient's death. Autopsy examination revealed the presence of peripheral nerve metastases as well. A review of the literature disclosed fewer than 10 cases of central nervous system metastasis from thymoma. In only 2 of these were there clinicopathologic features similar to those seen in this case.

Original languageEnglish (US)
Pages (from-to)2036-2043
Number of pages8
JournalCancer
Volume47
Issue number8
DOIs
StatePublished - 1981

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Thymoma
Peripheral Nervous System
Central Nervous System
Neoplasm Metastasis
Thoracic Diseases
Cranial Nerves
Peripheral Nerves
Brain Stem
Autopsy
Neoplasms
Radiotherapy
T-Lymphocytes
Drug Therapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Malignant, predominantly lymphocytic thymoma with central and peripheral nervous system metastases. / Wick, M. R.; Nichols, W. C.; Ingle, J. N.; Bruckman, J. E.; Okazaki, H.

In: Cancer, Vol. 47, No. 8, 1981, p. 2036-2043.

Research output: Contribution to journalArticle

Wick, M. R. ; Nichols, W. C. ; Ingle, J. N. ; Bruckman, J. E. ; Okazaki, H. / Malignant, predominantly lymphocytic thymoma with central and peripheral nervous system metastases. In: Cancer. 1981 ; Vol. 47, No. 8. pp. 2036-2043.
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