Malignant peripheral nerve sheath tumors of the eighth cranial nerve arising without prior irradiation

Matthew L. Carlson, Jeffrey T. Jacob, Elizabeth B Habermann, Amy E. Glasgow, Aditya Raghunathan, Michael J. Link

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective Malignant peripheral nerve sheath tumors (MPNSTs) of the eighth cranial nerve (CN) are exceedingly rare. To date the literature has focused on MPNSTs occurring after radiation therapy for presumed benign vestibular schwannomas (VSs), while MPNSTs arising without prior irradiation have received little attention. The objectives of the current study are to characterize the epidemiology, clinical presentation, disease course, and outcome using a large national cancer registry database and a systematic review of the English literature. Additionally, a previously unreported case is presented. methods The authors conducted an analysis of the Surveillance, Epidemiology, and End Results (SEER) database, a systematic review of the literature, and present a case report. Data from all patients identifed in the SEER database with a diagnosis of MPNST involving the eighth CN, without a history of prior radiation, were analyzed. Additionally, all cases reported in the English literature between January 1980 and March 2015 were reviewed. Finally, 1 previously unreported case is presented. results The SEER registries identifed 30 cases between 1992 and 2012. The average incidence was 0.017 per 1 million persons per year (range 0.000-0.0687 per year). The median age at diagnosis was 55 years, and 16 (53%) were women. Thirteen cases were diagnosed upon autopsy. Of the 17 cases diagnosed while alive, the median follow-up was 118 days, with 3 deaths (18%) observed. When compared with the incidence of benign VS, 1041 VSs present for every 1 MPNST arising from the eighth CN. Including a previously unreported case from the authors' center, a systematic review of the English literature yielded 24 reports. The median age at diagnosis was 44 years, 50% were women, and the median tumor size at diagnosis was 3 cm. Eleven patients (46%) reported isolated audiovestibular complaints typical for VS while 13 (54%) exhibited facial paresis or other signs of a more aggressive process. Treatment included microsurgery alone, microsurgery with adjuvant radiation, or microsurgery with chemoradiation. Sixty-one percent of patients receiving treatment experienced recurrence, 22% of which were diagnosed with drop metastases to the spine. Ultimately, 13 patients (54%) died of progressive disease at a median of 3 months following diagnosis. The ability to achieve gross-total resection was the only feature that was associated with improved disease-specifc survival. coNclusioNs MPNSTs of the eighth CN are extremely rare and portend a poor prognosis. Nearly half of patients initially present with fndings consistent with a benign VS, often making an early diagnosis challenging. In light of these data, early radiological and clinical follow-up should be considered in those who elect nonoperative treatment, particularly in patients with a short duration of symptoms or atypical presentation. These data also provide a baseline rate of malignancy that should be considered when estimating the risk of malignant transformation following stereotactic radiosurgery for VS.

Original languageEnglish (US)
Pages (from-to)1120-1129
Number of pages10
JournalJournal of Neurosurgery
Volume125
Issue number5
DOIs
StatePublished - Nov 1 2016

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Vestibulocochlear Nerve
Acoustic Neuroma
Neurilemmoma
Microsurgery
Epidemiology
Databases
Registries
Radiation
Literature
Neoplasms
Radiosurgery
Facial Paralysis
Incidence
Early Diagnosis
Autopsy
Spine
Radiotherapy
Therapeutics
Neoplasm Metastasis
Recurrence

Keywords

  • Acoustic neuroma
  • Cerebellopontine angle
  • Epithelioid schwannoma
  • Gamma Knife radiosurgery
  • Malignant
  • Melanocytic schwannoma
  • Microsurgery
  • Neurofibrosarcoma
  • Oncology
  • Peripheral nerve sheath tumor
  • Stereotactic radiosurgery
  • Vestibular schwannoma

ASJC Scopus subject areas

  • Surgery
  • Medicine(all)
  • Clinical Neurology

Cite this

Malignant peripheral nerve sheath tumors of the eighth cranial nerve arising without prior irradiation. / Carlson, Matthew L.; Jacob, Jeffrey T.; Habermann, Elizabeth B; Glasgow, Amy E.; Raghunathan, Aditya; Link, Michael J.

In: Journal of Neurosurgery, Vol. 125, No. 5, 01.11.2016, p. 1120-1129.

Research output: Contribution to journalArticle

Carlson, Matthew L. ; Jacob, Jeffrey T. ; Habermann, Elizabeth B ; Glasgow, Amy E. ; Raghunathan, Aditya ; Link, Michael J. / Malignant peripheral nerve sheath tumors of the eighth cranial nerve arising without prior irradiation. In: Journal of Neurosurgery. 2016 ; Vol. 125, No. 5. pp. 1120-1129.
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title = "Malignant peripheral nerve sheath tumors of the eighth cranial nerve arising without prior irradiation",
abstract = "Objective Malignant peripheral nerve sheath tumors (MPNSTs) of the eighth cranial nerve (CN) are exceedingly rare. To date the literature has focused on MPNSTs occurring after radiation therapy for presumed benign vestibular schwannomas (VSs), while MPNSTs arising without prior irradiation have received little attention. The objectives of the current study are to characterize the epidemiology, clinical presentation, disease course, and outcome using a large national cancer registry database and a systematic review of the English literature. Additionally, a previously unreported case is presented. methods The authors conducted an analysis of the Surveillance, Epidemiology, and End Results (SEER) database, a systematic review of the literature, and present a case report. Data from all patients identifed in the SEER database with a diagnosis of MPNST involving the eighth CN, without a history of prior radiation, were analyzed. Additionally, all cases reported in the English literature between January 1980 and March 2015 were reviewed. Finally, 1 previously unreported case is presented. results The SEER registries identifed 30 cases between 1992 and 2012. The average incidence was 0.017 per 1 million persons per year (range 0.000-0.0687 per year). The median age at diagnosis was 55 years, and 16 (53{\%}) were women. Thirteen cases were diagnosed upon autopsy. Of the 17 cases diagnosed while alive, the median follow-up was 118 days, with 3 deaths (18{\%}) observed. When compared with the incidence of benign VS, 1041 VSs present for every 1 MPNST arising from the eighth CN. Including a previously unreported case from the authors' center, a systematic review of the English literature yielded 24 reports. The median age at diagnosis was 44 years, 50{\%} were women, and the median tumor size at diagnosis was 3 cm. Eleven patients (46{\%}) reported isolated audiovestibular complaints typical for VS while 13 (54{\%}) exhibited facial paresis or other signs of a more aggressive process. Treatment included microsurgery alone, microsurgery with adjuvant radiation, or microsurgery with chemoradiation. Sixty-one percent of patients receiving treatment experienced recurrence, 22{\%} of which were diagnosed with drop metastases to the spine. Ultimately, 13 patients (54{\%}) died of progressive disease at a median of 3 months following diagnosis. The ability to achieve gross-total resection was the only feature that was associated with improved disease-specifc survival. coNclusioNs MPNSTs of the eighth CN are extremely rare and portend a poor prognosis. Nearly half of patients initially present with fndings consistent with a benign VS, often making an early diagnosis challenging. In light of these data, early radiological and clinical follow-up should be considered in those who elect nonoperative treatment, particularly in patients with a short duration of symptoms or atypical presentation. These data also provide a baseline rate of malignancy that should be considered when estimating the risk of malignant transformation following stereotactic radiosurgery for VS.",
keywords = "Acoustic neuroma, Cerebellopontine angle, Epithelioid schwannoma, Gamma Knife radiosurgery, Malignant, Melanocytic schwannoma, Microsurgery, Neurofibrosarcoma, Oncology, Peripheral nerve sheath tumor, Stereotactic radiosurgery, Vestibular schwannoma",
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TY - JOUR

T1 - Malignant peripheral nerve sheath tumors of the eighth cranial nerve arising without prior irradiation

AU - Carlson, Matthew L.

AU - Jacob, Jeffrey T.

AU - Habermann, Elizabeth B

AU - Glasgow, Amy E.

AU - Raghunathan, Aditya

AU - Link, Michael J.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Objective Malignant peripheral nerve sheath tumors (MPNSTs) of the eighth cranial nerve (CN) are exceedingly rare. To date the literature has focused on MPNSTs occurring after radiation therapy for presumed benign vestibular schwannomas (VSs), while MPNSTs arising without prior irradiation have received little attention. The objectives of the current study are to characterize the epidemiology, clinical presentation, disease course, and outcome using a large national cancer registry database and a systematic review of the English literature. Additionally, a previously unreported case is presented. methods The authors conducted an analysis of the Surveillance, Epidemiology, and End Results (SEER) database, a systematic review of the literature, and present a case report. Data from all patients identifed in the SEER database with a diagnosis of MPNST involving the eighth CN, without a history of prior radiation, were analyzed. Additionally, all cases reported in the English literature between January 1980 and March 2015 were reviewed. Finally, 1 previously unreported case is presented. results The SEER registries identifed 30 cases between 1992 and 2012. The average incidence was 0.017 per 1 million persons per year (range 0.000-0.0687 per year). The median age at diagnosis was 55 years, and 16 (53%) were women. Thirteen cases were diagnosed upon autopsy. Of the 17 cases diagnosed while alive, the median follow-up was 118 days, with 3 deaths (18%) observed. When compared with the incidence of benign VS, 1041 VSs present for every 1 MPNST arising from the eighth CN. Including a previously unreported case from the authors' center, a systematic review of the English literature yielded 24 reports. The median age at diagnosis was 44 years, 50% were women, and the median tumor size at diagnosis was 3 cm. Eleven patients (46%) reported isolated audiovestibular complaints typical for VS while 13 (54%) exhibited facial paresis or other signs of a more aggressive process. Treatment included microsurgery alone, microsurgery with adjuvant radiation, or microsurgery with chemoradiation. Sixty-one percent of patients receiving treatment experienced recurrence, 22% of which were diagnosed with drop metastases to the spine. Ultimately, 13 patients (54%) died of progressive disease at a median of 3 months following diagnosis. The ability to achieve gross-total resection was the only feature that was associated with improved disease-specifc survival. coNclusioNs MPNSTs of the eighth CN are extremely rare and portend a poor prognosis. Nearly half of patients initially present with fndings consistent with a benign VS, often making an early diagnosis challenging. In light of these data, early radiological and clinical follow-up should be considered in those who elect nonoperative treatment, particularly in patients with a short duration of symptoms or atypical presentation. These data also provide a baseline rate of malignancy that should be considered when estimating the risk of malignant transformation following stereotactic radiosurgery for VS.

AB - Objective Malignant peripheral nerve sheath tumors (MPNSTs) of the eighth cranial nerve (CN) are exceedingly rare. To date the literature has focused on MPNSTs occurring after radiation therapy for presumed benign vestibular schwannomas (VSs), while MPNSTs arising without prior irradiation have received little attention. The objectives of the current study are to characterize the epidemiology, clinical presentation, disease course, and outcome using a large national cancer registry database and a systematic review of the English literature. Additionally, a previously unreported case is presented. methods The authors conducted an analysis of the Surveillance, Epidemiology, and End Results (SEER) database, a systematic review of the literature, and present a case report. Data from all patients identifed in the SEER database with a diagnosis of MPNST involving the eighth CN, without a history of prior radiation, were analyzed. Additionally, all cases reported in the English literature between January 1980 and March 2015 were reviewed. Finally, 1 previously unreported case is presented. results The SEER registries identifed 30 cases between 1992 and 2012. The average incidence was 0.017 per 1 million persons per year (range 0.000-0.0687 per year). The median age at diagnosis was 55 years, and 16 (53%) were women. Thirteen cases were diagnosed upon autopsy. Of the 17 cases diagnosed while alive, the median follow-up was 118 days, with 3 deaths (18%) observed. When compared with the incidence of benign VS, 1041 VSs present for every 1 MPNST arising from the eighth CN. Including a previously unreported case from the authors' center, a systematic review of the English literature yielded 24 reports. The median age at diagnosis was 44 years, 50% were women, and the median tumor size at diagnosis was 3 cm. Eleven patients (46%) reported isolated audiovestibular complaints typical for VS while 13 (54%) exhibited facial paresis or other signs of a more aggressive process. Treatment included microsurgery alone, microsurgery with adjuvant radiation, or microsurgery with chemoradiation. Sixty-one percent of patients receiving treatment experienced recurrence, 22% of which were diagnosed with drop metastases to the spine. Ultimately, 13 patients (54%) died of progressive disease at a median of 3 months following diagnosis. The ability to achieve gross-total resection was the only feature that was associated with improved disease-specifc survival. coNclusioNs MPNSTs of the eighth CN are extremely rare and portend a poor prognosis. Nearly half of patients initially present with fndings consistent with a benign VS, often making an early diagnosis challenging. In light of these data, early radiological and clinical follow-up should be considered in those who elect nonoperative treatment, particularly in patients with a short duration of symptoms or atypical presentation. These data also provide a baseline rate of malignancy that should be considered when estimating the risk of malignant transformation following stereotactic radiosurgery for VS.

KW - Acoustic neuroma

KW - Cerebellopontine angle

KW - Epithelioid schwannoma

KW - Gamma Knife radiosurgery

KW - Malignant

KW - Melanocytic schwannoma

KW - Microsurgery

KW - Neurofibrosarcoma

KW - Oncology

KW - Peripheral nerve sheath tumor

KW - Stereotactic radiosurgery

KW - Vestibular schwannoma

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