TY - JOUR
T1 - Malignant glioma progression and nitric oxide
AU - Lam-Himlin, Dora
AU - Espey, Michael G.
AU - Perry, George
AU - Smith, Mark A.
AU - Castellani, Rudy J.
N1 - Funding Information:
Work in the authors’ laboratories is supported by the National Institutes of Health, the Alzheimer's Association, Philip Morris USA Inc. and Philip Morris International.
PY - 2006/12
Y1 - 2006/12
N2 - Glioblastoma multiforme, the most common of the malignant gliomas, carries a dismal prognosis in spite of the most aggressive therapy and recent advances in molecular pathways of glioma progression. Although it has received relatively little attention in the setting of malignant gliomas, nitric oxide metabolism may be intimately associated with the disease process. Interestingly, nitric oxide has both physiological roles (e.g., neurotransmitter-like activity, stimulation of cyclic GMP), and pathophysiological roles (e.g., neoplastic transformation, tumor neovascularization, induction of apoptosis, free radical damage). Moreover, whether nitric oxide is neuroprotective or neurotoxic in a given disease state, or whether it enhances or diminishes chemotherapeutic efficacy in malignant neoplasia, is unresolved. This review discusses the multifaceted activity of nitric oxide with particular reference to malignant gliomas.
AB - Glioblastoma multiforme, the most common of the malignant gliomas, carries a dismal prognosis in spite of the most aggressive therapy and recent advances in molecular pathways of glioma progression. Although it has received relatively little attention in the setting of malignant gliomas, nitric oxide metabolism may be intimately associated with the disease process. Interestingly, nitric oxide has both physiological roles (e.g., neurotransmitter-like activity, stimulation of cyclic GMP), and pathophysiological roles (e.g., neoplastic transformation, tumor neovascularization, induction of apoptosis, free radical damage). Moreover, whether nitric oxide is neuroprotective or neurotoxic in a given disease state, or whether it enhances or diminishes chemotherapeutic efficacy in malignant neoplasia, is unresolved. This review discusses the multifaceted activity of nitric oxide with particular reference to malignant gliomas.
KW - Glioblastoma multiforme
KW - Glioma
KW - Nitric oxide
KW - Nitric oxide synthase
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U2 - 10.1016/j.neuint.2006.07.001
DO - 10.1016/j.neuint.2006.07.001
M3 - Article
C2 - 16971023
AN - SCOPUS:33750473731
SN - 0197-0186
VL - 49
SP - 764
EP - 768
JO - Neurochemistry International
JF - Neurochemistry International
IS - 8
ER -