TY - JOUR
T1 - Making a case for endovascular approaches for neural recording and stimulation
AU - Thielen, Brianna
AU - Xu, Huijing
AU - Fujii, Tatsuhiro
AU - Rangwala, Shivani D.
AU - Jiang, Wenxuan
AU - Lin, Michelle
AU - Kammen, Alexandra
AU - Liu, Charles
AU - Selvan, Pradeep
AU - Song, Dong
AU - Mack, William J.
AU - Meng, Ellis
N1 - Funding Information:
This work was in part funded by the University of Southern California Provost New Directions in Research and Scholarship Award and the NIH/NINDS under Award Number 1U24NS113647.
Publisher Copyright:
© 2023 IOP Publishing Ltd.
PY - 2023/2/1
Y1 - 2023/2/1
N2 - There are many electrode types for recording and stimulating neural tissue, most of which necessitate direct contact with the target tissue. These electrodes range from large, scalp electrodes which are used to non-invasively record averaged, low frequency electrical signals from large areas/volumes of the brain, to penetrating microelectrodes which are implanted directly into neural tissue and interface with one or a few neurons. With the exception of scalp electrodes (which provide very low-resolution recordings), each of these electrodes requires a highly invasive, open brain surgical procedure for implantation, which is accompanied by significant risk to the patient. To mitigate this risk, a minimally invasive endovascular approach can be used. Several types of endovascular electrodes have been developed to be delivered into the blood vessels in the brain via a standard catheterization procedure. In this review, the existing body of research on the development and application of endovascular electrodes is presented. The capabilities of each of these endovascular electrodes is compared to commonly used direct-contact electrodes to demonstrate the relative efficacy of the devices. Potential clinical applications of endovascular recording and stimulation and the advantages of endovascular versus direct-contact approaches are presented.
AB - There are many electrode types for recording and stimulating neural tissue, most of which necessitate direct contact with the target tissue. These electrodes range from large, scalp electrodes which are used to non-invasively record averaged, low frequency electrical signals from large areas/volumes of the brain, to penetrating microelectrodes which are implanted directly into neural tissue and interface with one or a few neurons. With the exception of scalp electrodes (which provide very low-resolution recordings), each of these electrodes requires a highly invasive, open brain surgical procedure for implantation, which is accompanied by significant risk to the patient. To mitigate this risk, a minimally invasive endovascular approach can be used. Several types of endovascular electrodes have been developed to be delivered into the blood vessels in the brain via a standard catheterization procedure. In this review, the existing body of research on the development and application of endovascular electrodes is presented. The capabilities of each of these endovascular electrodes is compared to commonly used direct-contact electrodes to demonstrate the relative efficacy of the devices. Potential clinical applications of endovascular recording and stimulation and the advantages of endovascular versus direct-contact approaches are presented.
KW - endovascular electrode
KW - endovascular recording
KW - minimally invasive
KW - neural interface
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U2 - 10.1088/1741-2552/acb086
DO - 10.1088/1741-2552/acb086
M3 - Review article
C2 - 36603221
AN - SCOPUS:85147047808
SN - 1741-2560
VL - 20
JO - Journal of Neural Engineering
JF - Journal of Neural Engineering
IS - 1
M1 - 011001
ER -