TY - JOUR
T1 - Major weight loss prevents long-term left atrial enlargement in patients with morbid and extreme obesity
AU - Garza, Carolina A.
AU - Pellikka, Patricia A.
AU - Somers, Virend K.
AU - Sarr, Michael G.
AU - Seward, James B.
AU - Collazo-Clavell, Maria L.
AU - Oehler, Elise
AU - Lopez-Jimenez, Francisco
PY - 2008/9
Y1 - 2008/9
N2 - Aims: To assess long-term changes in left atrial (LA) volume in patients with morbid obesity [body mass index (BMI) ≥35 kg/m2 with co-morbidities] and extreme obesity (BMI ≥40 kg/m2), after surgically-induced weight loss (WL) after gastric bypass surgery. Methods and results: We reviewed 57 patients who underwent gastric bypass surgery and had echocardiograms both before and after the operation. A control group was frequency-matched for BMI, sex, age, and for duration of follow-up. After a mean follow-up of 3.6 years, LA volume did not change significantly in patients who underwent bariatric surgery, but increased in the control group by 15 ± 28 ml (P < 0.0001), and 0.1 ± 0.2 ml (P < 0.0001) for height-indexed LA volume, with a difference between cases and controls that remained significant after adjusting for potential confounders (P = 0.01). In the study population as a whole, there was a positive correlation between change in body weight and change in LA volume (r = 0.22, P = 0.006) independent of clinical conditions associated with LA enlargement. Conclusion: Change in body weight is associated with change in LA size independent of obesity-associated co-morbidities. Successful WL induced by bariatric surgery prevents the progressive increase in LA volume.
AB - Aims: To assess long-term changes in left atrial (LA) volume in patients with morbid obesity [body mass index (BMI) ≥35 kg/m2 with co-morbidities] and extreme obesity (BMI ≥40 kg/m2), after surgically-induced weight loss (WL) after gastric bypass surgery. Methods and results: We reviewed 57 patients who underwent gastric bypass surgery and had echocardiograms both before and after the operation. A control group was frequency-matched for BMI, sex, age, and for duration of follow-up. After a mean follow-up of 3.6 years, LA volume did not change significantly in patients who underwent bariatric surgery, but increased in the control group by 15 ± 28 ml (P < 0.0001), and 0.1 ± 0.2 ml (P < 0.0001) for height-indexed LA volume, with a difference between cases and controls that remained significant after adjusting for potential confounders (P = 0.01). In the study population as a whole, there was a positive correlation between change in body weight and change in LA volume (r = 0.22, P = 0.006) independent of clinical conditions associated with LA enlargement. Conclusion: Change in body weight is associated with change in LA size independent of obesity-associated co-morbidities. Successful WL induced by bariatric surgery prevents the progressive increase in LA volume.
KW - Bariatric surgery
KW - Diastolic function
KW - Left atrial volume
KW - Obesity
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U2 - 10.1093/ejechocard/jen117
DO - 10.1093/ejechocard/jen117
M3 - Article
C2 - 18490311
AN - SCOPUS:58149359345
SN - 2047-2404
VL - 9
SP - 587
EP - 593
JO - European Heart Journal Cardiovascular Imaging
JF - European Heart Journal Cardiovascular Imaging
IS - 5
ER -