Major histocompatibility complex genes and susceptibility to systemic Lupus erythematosus in Northern India

N. K. Mehra, I. Pande, Veena D Taneja, S. S. Uppal, S. P. Saxena, A. Kumar, A. N. Malaviya

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Fifty-eight patients with systemic lupus erythematosus (SLE) from Northern India were tissue typed for HLA class I and II antigens. The results revealed an appreciable increase of HLA-DR4 (37.5%) among patients compared with controls (17.9%), P < 0.03. Additionally, haplotype B8-DR3 was encountered frequently in the patient group. The findings suggest an important role of MHC genes in influencing susceptibility to SLE.

Original languageEnglish (US)
Pages (from-to)313-314
Number of pages2
JournalLupus
Volume2
Issue number5
StatePublished - 1993
Externally publishedYes

Fingerprint

Major Histocompatibility Complex
Systemic Lupus Erythematosus
India
HLA-DR4 Antigen
Genes
Histocompatibility Antigens Class I
Histocompatibility Antigens Class II
HLA Antigens
Haplotypes

Keywords

  • Asian Indians
  • Major histocompatibility complex (MHC)
  • SLE

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Mehra, N. K., Pande, I., Taneja, V. D., Uppal, S. S., Saxena, S. P., Kumar, A., & Malaviya, A. N. (1993). Major histocompatibility complex genes and susceptibility to systemic Lupus erythematosus in Northern India. Lupus, 2(5), 313-314.

Major histocompatibility complex genes and susceptibility to systemic Lupus erythematosus in Northern India. / Mehra, N. K.; Pande, I.; Taneja, Veena D; Uppal, S. S.; Saxena, S. P.; Kumar, A.; Malaviya, A. N.

In: Lupus, Vol. 2, No. 5, 1993, p. 313-314.

Research output: Contribution to journalArticle

Mehra, NK, Pande, I, Taneja, VD, Uppal, SS, Saxena, SP, Kumar, A & Malaviya, AN 1993, 'Major histocompatibility complex genes and susceptibility to systemic Lupus erythematosus in Northern India', Lupus, vol. 2, no. 5, pp. 313-314.
Mehra, N. K. ; Pande, I. ; Taneja, Veena D ; Uppal, S. S. ; Saxena, S. P. ; Kumar, A. ; Malaviya, A. N. / Major histocompatibility complex genes and susceptibility to systemic Lupus erythematosus in Northern India. In: Lupus. 1993 ; Vol. 2, No. 5. pp. 313-314.
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