Major Histocompatibility Complex Genes and Susceptibility to Systemic Lupus Erythematosus in Northern India

N. K. Mehra, Ira Pande, Veena Taneja, S. S. Uppal, S. P. Saxena, A. Kumar, A. N. Malaviya

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Fifty-eight patients with systemic lupus erythematosus (SLE) from Northern India were tissue typed for HLA class I and II antigens. The results revealed an appreciable increase of HLA-DR4 (37.5%) among patients compared with controls (17.9%), P < 0.03. Additionally, haplotype B8-DR3 was encountered frequently in the patient group. The findings suggest an important role of MHC genes in influencing susceptibility to SLE.

Original languageEnglish (US)
Pages (from-to)313-314
Number of pages2
JournalLupus
Volume2
Issue number5
DOIs
StatePublished - Oct 1993

Keywords

  • Asian Indians
  • Major histocompatibility complex (MHC)
  • SLE

ASJC Scopus subject areas

  • Rheumatology

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