TY - JOUR
T1 - Major histocompatibility complex class I chain-related gene a polymorphisms and extended haplotypes are associated with familial alopecia areata
AU - Barahmani, Nazila
AU - De Andrade, Mariza
AU - Slusser, Joshua P.
AU - Zhang, Qing
AU - Duvic, Madeleine
N1 - Funding Information:
This work was supported by the National Institute of Arthritis and Musculoskeletal and Skin (NIAMS) Grant AR45789, K24-CA86815, the National Alopecia Areata Foundation (NAAF) research grant, and the grant from Zarrow Family Foundation. This work was presented at the May 2004 meeting of the Society of Investigative Dermatology, in Providence, RI. We thank The University of Texas MD Anderson Cancer Center's core-laboratory facility, funded by NCI Grant CA-16672 (DNA Analysis Core Facility), for performing tests with the ABI 3100 and AB 3730XL Genetic Analyzer.
PY - 2006/1
Y1 - 2006/1
N2 - Alopecia areata (AA) is characterized by hair loss in patches and may progress to total loss of scalp hair, or total loss of scalp and body hair. The major histocompatibility complex (HLA) is associated with susceptibility to AA, as well as other autoimmune diseases. In addition to HLA molecules, non-HLA molecules including the major histocompatibility complex class I chain-related gene A (MICA), a stress-inducible antigen, are also associated with several autoimmune diseases. To investigate associations between AA and the HLA loci, two genes and eight microsatellite markers spanning the HLA region were genotyped. MICA*6 was significantly associated with all phenotypes of AA (P=0.0083), whereas MICA*5.1 was significantly associated with patchy AA (P=0.029). Extended haplotype analysis shows the significant associations of haplotypes HLA-DQ1-DR6-MICA*5.1 (P=0.004) and HLA-DQB1*0201-DR3- MICA*5.1 (P=0.009) with AA. These results suggest that MICA is both a potential candidate gene and part of an extended HLA haplotype that may contribute to susceptibility to and severity of AA.
AB - Alopecia areata (AA) is characterized by hair loss in patches and may progress to total loss of scalp hair, or total loss of scalp and body hair. The major histocompatibility complex (HLA) is associated with susceptibility to AA, as well as other autoimmune diseases. In addition to HLA molecules, non-HLA molecules including the major histocompatibility complex class I chain-related gene A (MICA), a stress-inducible antigen, are also associated with several autoimmune diseases. To investigate associations between AA and the HLA loci, two genes and eight microsatellite markers spanning the HLA region were genotyped. MICA*6 was significantly associated with all phenotypes of AA (P=0.0083), whereas MICA*5.1 was significantly associated with patchy AA (P=0.029). Extended haplotype analysis shows the significant associations of haplotypes HLA-DQ1-DR6-MICA*5.1 (P=0.004) and HLA-DQB1*0201-DR3- MICA*5.1 (P=0.009) with AA. These results suggest that MICA is both a potential candidate gene and part of an extended HLA haplotype that may contribute to susceptibility to and severity of AA.
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U2 - 10.1038/sj.jid.5700009
DO - 10.1038/sj.jid.5700009
M3 - Article
C2 - 16417220
AN - SCOPUS:33644784807
SN - 0022-202X
VL - 126
SP - 74
EP - 78
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 1
ER -