Major depression, panic disorder, and mitral valve prolapse in patients who complain of chest pain

Robert M. Carney, Kenneth E. Freedland, Philip A. Ludbrook, Roger D. Saunders, Allan S Jaffe

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

purpose: Patients with chest pain but without angiographic evidence of significant atherosclerotic coronary artery disease (CAD) are often found to have other medical or psychiatric disorders, including mitral valve prolapse, panic disorder (PD), and major depressive disorder (MDD). The purpose of this study was to determine the degree of comorbidity between MDD/PD and mitral valve prolapse in a group of patients with non-CAD chest pain. patients and methods: Patients referred for cardiac catheterization and coronary angiography for suspected CAD who were 70 years of age or younger and without other significant medical illnesses or cardiac complications were eligible for study. The first 100 patients who agreed to a psychiatric diagnostic interview were recruited. results: Forty-eight of the 100 patients were found to be without significant CAD. Forty-two percent of these patients, compared to 19% of the patients with significant CAD, were found to have either MDD, PD, or both. Eighty percent of the patients without CAD who had mitral valve prolapse also had either MDD or PD (p <0.006). conclusions: The finding that mitral valve prolapse was significantly associated with MDD/PD has implications for the diagnosis and treatment of patients with non-CAD chest pain, and may explain why these patients complain of symptoms.

Original languageEnglish (US)
Pages (from-to)757-760
Number of pages4
JournalThe American journal of medicine
Volume89
Issue number6
DOIs
StatePublished - 1990
Externally publishedYes

Fingerprint

Mitral Valve Prolapse
Panic Disorder
Chest Pain
Depression
Major Depressive Disorder
Coronary Artery Disease
Psychiatry
Arteries
Cardiac Catheterization
Coronary Angiography
Comorbidity
Interviews

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Major depression, panic disorder, and mitral valve prolapse in patients who complain of chest pain. / Carney, Robert M.; Freedland, Kenneth E.; Ludbrook, Philip A.; Saunders, Roger D.; Jaffe, Allan S.

In: The American journal of medicine, Vol. 89, No. 6, 1990, p. 757-760.

Research output: Contribution to journalArticle

Carney, Robert M. ; Freedland, Kenneth E. ; Ludbrook, Philip A. ; Saunders, Roger D. ; Jaffe, Allan S. / Major depression, panic disorder, and mitral valve prolapse in patients who complain of chest pain. In: The American journal of medicine. 1990 ; Vol. 89, No. 6. pp. 757-760.
@article{fbc0f10b03ee475d8a03ae129f3465af,
title = "Major depression, panic disorder, and mitral valve prolapse in patients who complain of chest pain",
abstract = "purpose: Patients with chest pain but without angiographic evidence of significant atherosclerotic coronary artery disease (CAD) are often found to have other medical or psychiatric disorders, including mitral valve prolapse, panic disorder (PD), and major depressive disorder (MDD). The purpose of this study was to determine the degree of comorbidity between MDD/PD and mitral valve prolapse in a group of patients with non-CAD chest pain. patients and methods: Patients referred for cardiac catheterization and coronary angiography for suspected CAD who were 70 years of age or younger and without other significant medical illnesses or cardiac complications were eligible for study. The first 100 patients who agreed to a psychiatric diagnostic interview were recruited. results: Forty-eight of the 100 patients were found to be without significant CAD. Forty-two percent of these patients, compared to 19{\%} of the patients with significant CAD, were found to have either MDD, PD, or both. Eighty percent of the patients without CAD who had mitral valve prolapse also had either MDD or PD (p <0.006). conclusions: The finding that mitral valve prolapse was significantly associated with MDD/PD has implications for the diagnosis and treatment of patients with non-CAD chest pain, and may explain why these patients complain of symptoms.",
author = "Carney, {Robert M.} and Freedland, {Kenneth E.} and Ludbrook, {Philip A.} and Saunders, {Roger D.} and Jaffe, {Allan S}",
year = "1990",
doi = "10.1016/0002-9343(90)90218-3",
language = "English (US)",
volume = "89",
pages = "757--760",
journal = "American Journal of Medicine",
issn = "0002-9343",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Major depression, panic disorder, and mitral valve prolapse in patients who complain of chest pain

AU - Carney, Robert M.

AU - Freedland, Kenneth E.

AU - Ludbrook, Philip A.

AU - Saunders, Roger D.

AU - Jaffe, Allan S

PY - 1990

Y1 - 1990

N2 - purpose: Patients with chest pain but without angiographic evidence of significant atherosclerotic coronary artery disease (CAD) are often found to have other medical or psychiatric disorders, including mitral valve prolapse, panic disorder (PD), and major depressive disorder (MDD). The purpose of this study was to determine the degree of comorbidity between MDD/PD and mitral valve prolapse in a group of patients with non-CAD chest pain. patients and methods: Patients referred for cardiac catheterization and coronary angiography for suspected CAD who were 70 years of age or younger and without other significant medical illnesses or cardiac complications were eligible for study. The first 100 patients who agreed to a psychiatric diagnostic interview were recruited. results: Forty-eight of the 100 patients were found to be without significant CAD. Forty-two percent of these patients, compared to 19% of the patients with significant CAD, were found to have either MDD, PD, or both. Eighty percent of the patients without CAD who had mitral valve prolapse also had either MDD or PD (p <0.006). conclusions: The finding that mitral valve prolapse was significantly associated with MDD/PD has implications for the diagnosis and treatment of patients with non-CAD chest pain, and may explain why these patients complain of symptoms.

AB - purpose: Patients with chest pain but without angiographic evidence of significant atherosclerotic coronary artery disease (CAD) are often found to have other medical or psychiatric disorders, including mitral valve prolapse, panic disorder (PD), and major depressive disorder (MDD). The purpose of this study was to determine the degree of comorbidity between MDD/PD and mitral valve prolapse in a group of patients with non-CAD chest pain. patients and methods: Patients referred for cardiac catheterization and coronary angiography for suspected CAD who were 70 years of age or younger and without other significant medical illnesses or cardiac complications were eligible for study. The first 100 patients who agreed to a psychiatric diagnostic interview were recruited. results: Forty-eight of the 100 patients were found to be without significant CAD. Forty-two percent of these patients, compared to 19% of the patients with significant CAD, were found to have either MDD, PD, or both. Eighty percent of the patients without CAD who had mitral valve prolapse also had either MDD or PD (p <0.006). conclusions: The finding that mitral valve prolapse was significantly associated with MDD/PD has implications for the diagnosis and treatment of patients with non-CAD chest pain, and may explain why these patients complain of symptoms.

UR - http://www.scopus.com/inward/record.url?scp=0025581899&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025581899&partnerID=8YFLogxK

U2 - 10.1016/0002-9343(90)90218-3

DO - 10.1016/0002-9343(90)90218-3

M3 - Article

C2 - 2252044

AN - SCOPUS:0025581899

VL - 89

SP - 757

EP - 760

JO - American Journal of Medicine

JF - American Journal of Medicine

SN - 0002-9343

IS - 6

ER -