Major depression is a risk factor for seizures in older adults

Dale C. Hesdorffer, W. Allen Hauser, John F. Annegers, Gregory D Cascino

Research output: Contribution to journalArticle

355 Citations (Scopus)

Abstract

We tested the hypothesis that major depression meeting DSM-III-R criteria or medical therapies for depression increase the risk for unprovoked seizures. Major depression was associated with a sixfold increased risk for unprovoked seizures (95% CI, 1.56-22). The risk remained increased even when controlling for age, sex, length of medical follow-up, and medical therapies for depression. In the absence of known prior neurological insult, major depression is associated with an increased risk for unprovoked seizures.

Original languageEnglish (US)
Pages (from-to)246-249
Number of pages4
JournalAnnals of Neurology
Volume47
Issue number2
DOIs
StatePublished - 2000

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Seizures
Diagnostic and Statistical Manual of Mental Disorders
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Major depression is a risk factor for seizures in older adults. / Hesdorffer, Dale C.; Hauser, W. Allen; Annegers, John F.; Cascino, Gregory D.

In: Annals of Neurology, Vol. 47, No. 2, 2000, p. 246-249.

Research output: Contribution to journalArticle

Hesdorffer, Dale C. ; Hauser, W. Allen ; Annegers, John F. ; Cascino, Gregory D. / Major depression is a risk factor for seizures in older adults. In: Annals of Neurology. 2000 ; Vol. 47, No. 2. pp. 246-249.
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