Magnitude- and time-dependence of the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats

Y. P. Kim, H. B. Kim, Mi-Hyeon D Jang, B. V. Lim, Y. J. Kim, H. Kim, S. S. Kim, E. H. Kim, C. J. Kim

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

The effect of treadmill exercise on cell proliferation in the dentate gyrus was studied in Sprague-Dawley rats via 5-bromo-2′-deoxyuridine (BrdU)-specific immunohistochemistry. For studying the dependence of this effect on the magnitude of exercise, animals were divided into the control, light-exercise, moderate-exercise, and severe-exercise groups; different exercise regimens were applied to the groups. To study the temporal dependence of this effect, animals were divided into the control, 1-day-exercise, 3-days-exercise, 7-days-exercise, 14-days-exercise, and 28-days-exercise groups; the regimen used on the light-exercise group was applied to each of the exercise group over the respective number of days. Cell proliferation was most prominent in the light-exercise group (p < 0.001) and reached a maximum level after 7 days of exercise (p < 0.001). In this study, it was shown that cell proliferation is modulated by the intensity and duration of treadmill exercise.

Original languageEnglish (US)
Pages (from-to)114-117
Number of pages4
JournalInternational Journal of Sports Medicine
Volume24
Issue number2
DOIs
StatePublished - Feb 2003
Externally publishedYes

Fingerprint

Dentate Gyrus
Cell Proliferation
Light
Bromodeoxyuridine
Sprague Dawley Rats
Immunohistochemistry

Keywords

  • 5-bromo-2′-deoxyuridine
  • Cell proliferation
  • Dentate gyrus
  • Exercise duration
  • Exercise intensity
  • Immunohistochemisty
  • Treadmill exercise

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Magnitude- and time-dependence of the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats. / Kim, Y. P.; Kim, H. B.; Jang, Mi-Hyeon D; Lim, B. V.; Kim, Y. J.; Kim, H.; Kim, S. S.; Kim, E. H.; Kim, C. J.

In: International Journal of Sports Medicine, Vol. 24, No. 2, 02.2003, p. 114-117.

Research output: Contribution to journalArticle

Kim, Y. P. ; Kim, H. B. ; Jang, Mi-Hyeon D ; Lim, B. V. ; Kim, Y. J. ; Kim, H. ; Kim, S. S. ; Kim, E. H. ; Kim, C. J. / Magnitude- and time-dependence of the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats. In: International Journal of Sports Medicine. 2003 ; Vol. 24, No. 2. pp. 114-117.
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