Abstract
Rationale and Objectives. Magnetic resonance imaging with magnetization transfer (MT) contrast recently has been described as a method that may provide additional information about the macromolecular composition of tissue. Magnetization transfer contrast images were compared to conventional gradient-recalled echo images in a variety of pulmonary parenchymal diseases and normal lung. Methods. Single-slice gradient echo images were obtained with and without an off-resonance radio frequency pulse on a 0.1T MR scanner. The change in signal intensity between identical regions of interest on non-MT and MT images was determined in 13 patients with known lung disease, five healthy volunteers, and three postmortem atelectatic dog lungs. Results. No significant change in signal intensity (MT effect) was observed in fat, flowing blood, normal lung, atelectatic lung, or in acute pulmonary edema. Chronic parenchymal lung disease showed the greatest MT effect, 37.7% ± 7.5. Acute infectious lung disease showed an intermediate degree of MT effect, 19.5% ± 3.0. Conclusions. Magnetization transfer contrast magnetic resonance imaging of pulmonary disease is feasible at low field strength and may be useful in the characterization and differentiation of pulmonary parenchymal abnormalities. Magnetization transfer contrast appears to be proportional to the amount of interstitial fibrosis in lung parenchyma, while acute inflammatory cell infiltration exhibits less MT effect and acute pulmonary edema exhibits very little.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 118-122 |
| Number of pages | 5 |
| Journal | Investigative Radiology |
| Volume | 30 |
| Issue number | 2 |
| State | Published - 1995 |
| Externally published | Yes |
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Keywords
- Magnetic resonance imaging
- Magnetization transfer contrast
- Pulmonary fibrosis pulmonary edema
- Pulmonary infections
- Tissue characterization
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
Magnetization transfer magnetic resonance imaging of parenchymal lung disease. / Kuzo, Ronald S; Kormano, Martti J.; Lipton, Martin J.
In: Investigative Radiology, Vol. 30, No. 2, 1995, p. 118-122.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Magnetization transfer magnetic resonance imaging of parenchymal lung disease
AU - Kuzo, Ronald S
AU - Kormano, Martti J.
AU - Lipton, Martin J.
PY - 1995
Y1 - 1995
N2 - Rationale and Objectives. Magnetic resonance imaging with magnetization transfer (MT) contrast recently has been described as a method that may provide additional information about the macromolecular composition of tissue. Magnetization transfer contrast images were compared to conventional gradient-recalled echo images in a variety of pulmonary parenchymal diseases and normal lung. Methods. Single-slice gradient echo images were obtained with and without an off-resonance radio frequency pulse on a 0.1T MR scanner. The change in signal intensity between identical regions of interest on non-MT and MT images was determined in 13 patients with known lung disease, five healthy volunteers, and three postmortem atelectatic dog lungs. Results. No significant change in signal intensity (MT effect) was observed in fat, flowing blood, normal lung, atelectatic lung, or in acute pulmonary edema. Chronic parenchymal lung disease showed the greatest MT effect, 37.7% ± 7.5. Acute infectious lung disease showed an intermediate degree of MT effect, 19.5% ± 3.0. Conclusions. Magnetization transfer contrast magnetic resonance imaging of pulmonary disease is feasible at low field strength and may be useful in the characterization and differentiation of pulmonary parenchymal abnormalities. Magnetization transfer contrast appears to be proportional to the amount of interstitial fibrosis in lung parenchyma, while acute inflammatory cell infiltration exhibits less MT effect and acute pulmonary edema exhibits very little.
AB - Rationale and Objectives. Magnetic resonance imaging with magnetization transfer (MT) contrast recently has been described as a method that may provide additional information about the macromolecular composition of tissue. Magnetization transfer contrast images were compared to conventional gradient-recalled echo images in a variety of pulmonary parenchymal diseases and normal lung. Methods. Single-slice gradient echo images were obtained with and without an off-resonance radio frequency pulse on a 0.1T MR scanner. The change in signal intensity between identical regions of interest on non-MT and MT images was determined in 13 patients with known lung disease, five healthy volunteers, and three postmortem atelectatic dog lungs. Results. No significant change in signal intensity (MT effect) was observed in fat, flowing blood, normal lung, atelectatic lung, or in acute pulmonary edema. Chronic parenchymal lung disease showed the greatest MT effect, 37.7% ± 7.5. Acute infectious lung disease showed an intermediate degree of MT effect, 19.5% ± 3.0. Conclusions. Magnetization transfer contrast magnetic resonance imaging of pulmonary disease is feasible at low field strength and may be useful in the characterization and differentiation of pulmonary parenchymal abnormalities. Magnetization transfer contrast appears to be proportional to the amount of interstitial fibrosis in lung parenchyma, while acute inflammatory cell infiltration exhibits less MT effect and acute pulmonary edema exhibits very little.
KW - Magnetic resonance imaging
KW - Magnetization transfer contrast
KW - Pulmonary fibrosis pulmonary edema
KW - Pulmonary infections
KW - Tissue characterization
UR - http://www.scopus.com/inward/record.url?scp=0028950334&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028950334&partnerID=8YFLogxK
M3 - Article
C2 - 7782187
AN - SCOPUS:0028950334
VL - 30
SP - 118
EP - 122
JO - Investigative Radiology
JF - Investigative Radiology
SN - 0020-9996
IS - 2
ER -