Magnetic resonance spectroscopy at term-equivalent age in extremely preterm infants: Association with cognitive and language development

Roopali Bapat, Ponnada A. Narayana, Yuxiang Zhou, Nehal A. Parikh

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

BACKGROUND: Proton magnetic resonance spectroscopy can be used to assess brain integrity and maturation with age. Objective To compare regional cerebral magnetic resonance spectroscopy metabolite ratios in extremely low birth weight and healthy term control infants measured at term-equivalent age and to evaluate association between magnetic resonance spectroscopy metabolites and cognitive and language development at 18-22 months' corrected age. METHODS: Single-voxel point-resolved spectroscopy sequence was performed in a prospective cohort of 43 infants. Magnetic resonance spectroscopy metabolite ratios of N-acetylaspartate to choline-containing compounds and N-acetylaspartate to myo-inositiol in the hippocampus, cortex, and subventricular zone were associated with Bayley mental, cognitive, and language scores at 18-22 months' corrected age. RESULTS: The mean (±S.D.) gestation of the 31 extremely low birth weight population was 25 (±1.1) weeks and mean (±S.D.) birth weight was 749 (±133.9) g. Compared with healthy term control infants, extremely low birth weight infants exhibited consistently lower N-acetylaspartate-to-choline- containing compounds ratios in our three regions of interest, with differences reaching statistical significance for the subventricular zone and cortex regions. In multiple linear regression analyses, N-acetylaspartate-to-choline- containing compounds ratio in the subventricular zone, N-acetylaspartate-to- choline-containing compounds ratio in the cortex, and N-acetylaspartate-to-myo- inositiol ratio in the subventricular zone were significantly associated with Bayley mental scores at 18-22 months' corrected age. CONCLUSIONS: Magnetic resonance spectroscopy metabolite abnormalities at term-equivalent age appear to be significantly associated with cognitive and language development in extremely low birth weight infants.

Original languageEnglish (US)
Pages (from-to)53-59
Number of pages7
JournalPediatric Neurology
Volume51
Issue number1
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Extremely Premature Infants
Language Development
Magnetic Resonance Spectroscopy
Lateral Ventricles
Choline
Extremely Low Birth Weight Infant
Low Birth Weight Infant
Birth Weight
N-acetylaspartate
Linear Models
Hippocampus
Spectrum Analysis
Language
Regression Analysis
Pregnancy
Brain
Population

Keywords

  • extremely low birth weight (ELBW) infants
  • extremely preterm infants
  • neurodevelopmental outcome
  • proton magnetic resonance spectroscopy (MRS)

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Magnetic resonance spectroscopy at term-equivalent age in extremely preterm infants : Association with cognitive and language development. / Bapat, Roopali; Narayana, Ponnada A.; Zhou, Yuxiang; Parikh, Nehal A.

In: Pediatric Neurology, Vol. 51, No. 1, 01.01.2014, p. 53-59.

Research output: Contribution to journalArticle

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abstract = "BACKGROUND: Proton magnetic resonance spectroscopy can be used to assess brain integrity and maturation with age. Objective To compare regional cerebral magnetic resonance spectroscopy metabolite ratios in extremely low birth weight and healthy term control infants measured at term-equivalent age and to evaluate association between magnetic resonance spectroscopy metabolites and cognitive and language development at 18-22 months' corrected age. METHODS: Single-voxel point-resolved spectroscopy sequence was performed in a prospective cohort of 43 infants. Magnetic resonance spectroscopy metabolite ratios of N-acetylaspartate to choline-containing compounds and N-acetylaspartate to myo-inositiol in the hippocampus, cortex, and subventricular zone were associated with Bayley mental, cognitive, and language scores at 18-22 months' corrected age. RESULTS: The mean (±S.D.) gestation of the 31 extremely low birth weight population was 25 (±1.1) weeks and mean (±S.D.) birth weight was 749 (±133.9) g. Compared with healthy term control infants, extremely low birth weight infants exhibited consistently lower N-acetylaspartate-to-choline- containing compounds ratios in our three regions of interest, with differences reaching statistical significance for the subventricular zone and cortex regions. In multiple linear regression analyses, N-acetylaspartate-to-choline- containing compounds ratio in the subventricular zone, N-acetylaspartate-to- choline-containing compounds ratio in the cortex, and N-acetylaspartate-to-myo- inositiol ratio in the subventricular zone were significantly associated with Bayley mental scores at 18-22 months' corrected age. CONCLUSIONS: Magnetic resonance spectroscopy metabolite abnormalities at term-equivalent age appear to be significantly associated with cognitive and language development in extremely low birth weight infants.",
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N2 - BACKGROUND: Proton magnetic resonance spectroscopy can be used to assess brain integrity and maturation with age. Objective To compare regional cerebral magnetic resonance spectroscopy metabolite ratios in extremely low birth weight and healthy term control infants measured at term-equivalent age and to evaluate association between magnetic resonance spectroscopy metabolites and cognitive and language development at 18-22 months' corrected age. METHODS: Single-voxel point-resolved spectroscopy sequence was performed in a prospective cohort of 43 infants. Magnetic resonance spectroscopy metabolite ratios of N-acetylaspartate to choline-containing compounds and N-acetylaspartate to myo-inositiol in the hippocampus, cortex, and subventricular zone were associated with Bayley mental, cognitive, and language scores at 18-22 months' corrected age. RESULTS: The mean (±S.D.) gestation of the 31 extremely low birth weight population was 25 (±1.1) weeks and mean (±S.D.) birth weight was 749 (±133.9) g. Compared with healthy term control infants, extremely low birth weight infants exhibited consistently lower N-acetylaspartate-to-choline- containing compounds ratios in our three regions of interest, with differences reaching statistical significance for the subventricular zone and cortex regions. In multiple linear regression analyses, N-acetylaspartate-to-choline- containing compounds ratio in the subventricular zone, N-acetylaspartate-to- choline-containing compounds ratio in the cortex, and N-acetylaspartate-to-myo- inositiol ratio in the subventricular zone were significantly associated with Bayley mental scores at 18-22 months' corrected age. CONCLUSIONS: Magnetic resonance spectroscopy metabolite abnormalities at term-equivalent age appear to be significantly associated with cognitive and language development in extremely low birth weight infants.

AB - BACKGROUND: Proton magnetic resonance spectroscopy can be used to assess brain integrity and maturation with age. Objective To compare regional cerebral magnetic resonance spectroscopy metabolite ratios in extremely low birth weight and healthy term control infants measured at term-equivalent age and to evaluate association between magnetic resonance spectroscopy metabolites and cognitive and language development at 18-22 months' corrected age. METHODS: Single-voxel point-resolved spectroscopy sequence was performed in a prospective cohort of 43 infants. Magnetic resonance spectroscopy metabolite ratios of N-acetylaspartate to choline-containing compounds and N-acetylaspartate to myo-inositiol in the hippocampus, cortex, and subventricular zone were associated with Bayley mental, cognitive, and language scores at 18-22 months' corrected age. RESULTS: The mean (±S.D.) gestation of the 31 extremely low birth weight population was 25 (±1.1) weeks and mean (±S.D.) birth weight was 749 (±133.9) g. Compared with healthy term control infants, extremely low birth weight infants exhibited consistently lower N-acetylaspartate-to-choline- containing compounds ratios in our three regions of interest, with differences reaching statistical significance for the subventricular zone and cortex regions. In multiple linear regression analyses, N-acetylaspartate-to-choline- containing compounds ratio in the subventricular zone, N-acetylaspartate-to- choline-containing compounds ratio in the cortex, and N-acetylaspartate-to-myo- inositiol ratio in the subventricular zone were significantly associated with Bayley mental scores at 18-22 months' corrected age. CONCLUSIONS: Magnetic resonance spectroscopy metabolite abnormalities at term-equivalent age appear to be significantly associated with cognitive and language development in extremely low birth weight infants.

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KW - neurodevelopmental outcome

KW - proton magnetic resonance spectroscopy (MRS)

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