Magnetic resonance measurements of renal blood flow and disease progression in autosomal dominant polycystic kidney disease

Vicente Torres, Bernard Francis King, Arlene B. Chapman, Marijn E. Brummer, Kyongtae T. Bae, James Glockner, Kraisthith Arya, Dana Risk, Joel P. Felmlee, Jared J. Grantham, Lisa M. Guay-Woodford, William M. Bennett, Saulo Klahr, Catherine M. Meyers, Xiaoling Zhang, Paul A. Thompson, J. Philip Miller

Research output: Contribution to journalArticle

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Abstract

Whether changes in renal blood flow (RBF) are associated with and possibly contribute to cystic disease progression in autosomal dominant polycystic kidney disease (ADPKD) has not been ascertained. The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) was created to develop imaging techniques and analyses to evaluate progression. A total of 131 participants with early ADPKD had measurements of RBF and total kidney (TKV) and cyst (TCV) volumes by magnetic resonance and of GFR by iothalamate clearance at baseline and 1, 2, and 3 yr. The effects of age, gender, body mass index, hypertension status, mean arterial pressure (MAP), TKV, TCV, RBF, renal vascular resistance (RVR), GFR, serum uric acid, HDL and LDL cholesterol, 24-h urine volume, sodium (UNaE) and albumin (UAE) excretions, and estimated protein intake were examined at baseline on TKV, TCV, and GFR slopes. TKV and TCV increased, RBF decreased, and GFR remained stable. TKV, TCV, RVR, serum uric acid, UAE, UNaE, age, body mass index, MAP, and estimated protein intake were positively and RBF and GFR negatively correlated with TKV and TCV slopes. TKV, RBF, UNaE, and UAE were independent predictors of TKV and TCV slopes (structural disease progression). TKV, TCV, RVR, and MAP were negatively and RBF positively correlated with GFR slopes. Regression to the mean confounded the analysis of GFR slopes. TKV and RBF were independent predictors of GFR decline (functional disease progression). In ADPKD, RBF reduction (1) parallels TKV increase, (2) precedes GFR decline, and (3) predicts structural and functional disease progression.

Original languageEnglish (US)
Pages (from-to)112-120
Number of pages9
JournalClinical Journal of the American Society of Nephrology
Volume2
Issue number1
DOIs
StatePublished - Jan 2007

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Autosomal Dominant Polycystic Kidney
Hematologic Diseases
Renal Circulation
Disease Progression
Magnetic Resonance Spectroscopy
Vascular Resistance
Kidney
Albumins
Arterial Pressure
Uric Acid
Body Mass Index
Iothalamic Acid
Polycystic Kidney Diseases
Serum
LDL Cholesterol
HDL Cholesterol
Cysts
Proteins
Sodium
Urine

ASJC Scopus subject areas

  • Nephrology
  • Transplantation
  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Medicine(all)

Cite this

Magnetic resonance measurements of renal blood flow and disease progression in autosomal dominant polycystic kidney disease. / Torres, Vicente; King, Bernard Francis; Chapman, Arlene B.; Brummer, Marijn E.; Bae, Kyongtae T.; Glockner, James; Arya, Kraisthith; Risk, Dana; Felmlee, Joel P.; Grantham, Jared J.; Guay-Woodford, Lisa M.; Bennett, William M.; Klahr, Saulo; Meyers, Catherine M.; Zhang, Xiaoling; Thompson, Paul A.; Miller, J. Philip.

In: Clinical Journal of the American Society of Nephrology, Vol. 2, No. 1, 01.2007, p. 112-120.

Research output: Contribution to journalArticle

Torres, V, King, BF, Chapman, AB, Brummer, ME, Bae, KT, Glockner, J, Arya, K, Risk, D, Felmlee, JP, Grantham, JJ, Guay-Woodford, LM, Bennett, WM, Klahr, S, Meyers, CM, Zhang, X, Thompson, PA & Miller, JP 2007, 'Magnetic resonance measurements of renal blood flow and disease progression in autosomal dominant polycystic kidney disease', Clinical Journal of the American Society of Nephrology, vol. 2, no. 1, pp. 112-120. https://doi.org/10.2215/CJN.00910306
Torres, Vicente ; King, Bernard Francis ; Chapman, Arlene B. ; Brummer, Marijn E. ; Bae, Kyongtae T. ; Glockner, James ; Arya, Kraisthith ; Risk, Dana ; Felmlee, Joel P. ; Grantham, Jared J. ; Guay-Woodford, Lisa M. ; Bennett, William M. ; Klahr, Saulo ; Meyers, Catherine M. ; Zhang, Xiaoling ; Thompson, Paul A. ; Miller, J. Philip. / Magnetic resonance measurements of renal blood flow and disease progression in autosomal dominant polycystic kidney disease. In: Clinical Journal of the American Society of Nephrology. 2007 ; Vol. 2, No. 1. pp. 112-120.
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AU - Grantham, Jared J.

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