Magnetic resonance markers for early diagnosis and progression of Alzheimer's disease

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

With increasing life expectancy, the early diagnosis and treatment of Alzheimer's disease has become critical in sustaining a healthy society. Noninvasive markers of disease progression starting from the earliest stages of pathologic involvement are required for determining the effectiveness of putative disease-modifying therapies that are under development. Cross-sectional and longitudinal studies indicate that magnetic resonance-based volume measurements of atrophy are potential markers of the progression of Alzheimer's disease, starting from the preclinical stages. Other magnetic resonance techniques that are sensitive to the different aspects of Alzheimer's disease pathology, such as biochemical (proton magnetic resonance spectroscopy), microstructural (diffusion magnetic resonance imaging), functional (functional magnetic resonance imaging) and blood flow (perfusion magnetic resonance imaging) changes, have not been as extensively studied longitudinally. Recent efforts of imaging amyloid plaques with magnetic resonance imaging generate the prospect for in vivo imaging of the pathologic substrate of Alzheimer's disease in the future. In order for magnetic resonance modalities to qualify as surrogate markers for early diagnosis and progression of Alzheimer's disease, multicenter longitudinal studies are needed.

Original languageEnglish (US)
Pages (from-to)663-670
Number of pages8
JournalExpert review of neurotherapeutics
Volume5
Issue number5
DOIs
StatePublished - Sep 1 2005

    Fingerprint

Keywords

  • Alzheimer's disease
  • Amyloid imaging
  • Dementia
  • Diffusion magnetic resonance imaging
  • Functional magnetic resonance imaging
  • Magnetic resonance imaging
  • Magnetic resonance spectroscopy
  • Mild cognitive impairment

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Pharmacology (medical)

Cite this