Magnetic resonance imaging of transverse acoustic strain waves

Raja Muthupillai, Phillip J. Rossman, David J. Lomas, James F Greenleaf, Stephen J Riederer, Richard Lorne Ehman

Research output: Contribution to journalArticle

205 Citations (Scopus)

Abstract

We describe a phase contrast based MRI technique with high sensitivity to cyclic displacement that is capable of quantitatively imaging acoustic strain waves in tissue-like materials. A formalism for considering gradient waveforms as basis functions to measure arbitrary cyclic motion waveforms is introduced. Experiments with tissue-like agarose gel phantoms show that it is possible to measure small cyclic displacements at a submicron level by an appropriate choice of the applied gradient basis function and to use this capability to observe the spatial and temporal pattern of displacements caused by acoustic strain waves. The propagation characteristics of strain waves are determined by the mechanical properties of the media. It is therefore possible to use this technique to noninvasively estimate material properties such as elastic modulus.

Original languageEnglish (US)
Pages (from-to)266-274
Number of pages9
JournalMagnetic Resonance in Medicine
Volume36
Issue number2
StatePublished - Aug 1996

Fingerprint

Magnetic Resonance Imaging
Elastic Modulus
Sepharose
Gels

Keywords

  • MR elastography
  • palpation
  • strain imaging
  • tissue elasticity
  • tumor detection

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Magnetic resonance imaging of transverse acoustic strain waves. / Muthupillai, Raja; Rossman, Phillip J.; Lomas, David J.; Greenleaf, James F; Riederer, Stephen J; Ehman, Richard Lorne.

In: Magnetic Resonance in Medicine, Vol. 36, No. 2, 08.1996, p. 266-274.

Research output: Contribution to journalArticle

@article{40228224e07340d59771c0b5e5fb1f04,
title = "Magnetic resonance imaging of transverse acoustic strain waves",
abstract = "We describe a phase contrast based MRI technique with high sensitivity to cyclic displacement that is capable of quantitatively imaging acoustic strain waves in tissue-like materials. A formalism for considering gradient waveforms as basis functions to measure arbitrary cyclic motion waveforms is introduced. Experiments with tissue-like agarose gel phantoms show that it is possible to measure small cyclic displacements at a submicron level by an appropriate choice of the applied gradient basis function and to use this capability to observe the spatial and temporal pattern of displacements caused by acoustic strain waves. The propagation characteristics of strain waves are determined by the mechanical properties of the media. It is therefore possible to use this technique to noninvasively estimate material properties such as elastic modulus.",
keywords = "MR elastography, palpation, strain imaging, tissue elasticity, tumor detection",
author = "Raja Muthupillai and Rossman, {Phillip J.} and Lomas, {David J.} and Greenleaf, {James F} and Riederer, {Stephen J} and Ehman, {Richard Lorne}",
year = "1996",
month = "8",
language = "English (US)",
volume = "36",
pages = "266--274",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - Magnetic resonance imaging of transverse acoustic strain waves

AU - Muthupillai, Raja

AU - Rossman, Phillip J.

AU - Lomas, David J.

AU - Greenleaf, James F

AU - Riederer, Stephen J

AU - Ehman, Richard Lorne

PY - 1996/8

Y1 - 1996/8

N2 - We describe a phase contrast based MRI technique with high sensitivity to cyclic displacement that is capable of quantitatively imaging acoustic strain waves in tissue-like materials. A formalism for considering gradient waveforms as basis functions to measure arbitrary cyclic motion waveforms is introduced. Experiments with tissue-like agarose gel phantoms show that it is possible to measure small cyclic displacements at a submicron level by an appropriate choice of the applied gradient basis function and to use this capability to observe the spatial and temporal pattern of displacements caused by acoustic strain waves. The propagation characteristics of strain waves are determined by the mechanical properties of the media. It is therefore possible to use this technique to noninvasively estimate material properties such as elastic modulus.

AB - We describe a phase contrast based MRI technique with high sensitivity to cyclic displacement that is capable of quantitatively imaging acoustic strain waves in tissue-like materials. A formalism for considering gradient waveforms as basis functions to measure arbitrary cyclic motion waveforms is introduced. Experiments with tissue-like agarose gel phantoms show that it is possible to measure small cyclic displacements at a submicron level by an appropriate choice of the applied gradient basis function and to use this capability to observe the spatial and temporal pattern of displacements caused by acoustic strain waves. The propagation characteristics of strain waves are determined by the mechanical properties of the media. It is therefore possible to use this technique to noninvasively estimate material properties such as elastic modulus.

KW - MR elastography

KW - palpation

KW - strain imaging

KW - tissue elasticity

KW - tumor detection

UR - http://www.scopus.com/inward/record.url?scp=0029741245&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029741245&partnerID=8YFLogxK

M3 - Article

C2 - 8843381

AN - SCOPUS:0029741245

VL - 36

SP - 266

EP - 274

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 2

ER -