Magnetic resonance imaging of amyloid plaques in transgenic mouse models of alzheimer's disease

Ryan Chamberlain, Thomas M. Wengenack, Joseph F. Poduslo, Michael Garwood, Clifford R Jr. Jack

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A major objective in the treatment of Alzheimer's disease is amyloid plaque reduction. Transgenic mouse models of Alzheimer's disease provide a controlled and consistent environment for studying amyloid plaque deposition in Alzheimer's disease. Magnetic resonance imaging is an attractive tool for longitudinal studies because it offers noninvasive monitoring of amyloid plaques. Recent studies have demonstrated the ability of magnetic resonance imaging to detect individual plaques in living mice. This review discusses the mouse models, MR pulse sequences, and parameters that have been used to image plaques and how they can be optimized for future studies.

Original languageEnglish (US)
Pages (from-to)3-7
Number of pages5
JournalCurrent Medical Imaging Reviews
Volume7
Issue number1
DOIs
StatePublished - Jun 2011

Fingerprint

Amyloid Plaques
Transgenic Mice
Alzheimer Disease
Magnetic Resonance Imaging
Controlled Environment
Aptitude
Longitudinal Studies

Keywords

  • Alzheimer's disease
  • Magnetic resonance imaging
  • Magnetic resonance micro imaging
  • MR microscopy
  • Transgenic mice

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Magnetic resonance imaging of amyloid plaques in transgenic mouse models of alzheimer's disease. / Chamberlain, Ryan; Wengenack, Thomas M.; Poduslo, Joseph F.; Garwood, Michael; Jack, Clifford R Jr.

In: Current Medical Imaging Reviews, Vol. 7, No. 1, 06.2011, p. 3-7.

Research output: Contribution to journalArticle

Chamberlain, Ryan ; Wengenack, Thomas M. ; Poduslo, Joseph F. ; Garwood, Michael ; Jack, Clifford R Jr. / Magnetic resonance imaging of amyloid plaques in transgenic mouse models of alzheimer's disease. In: Current Medical Imaging Reviews. 2011 ; Vol. 7, No. 1. pp. 3-7.
@article{62a40befd60d47248344e9d4fe14dda6,
title = "Magnetic resonance imaging of amyloid plaques in transgenic mouse models of alzheimer's disease",
abstract = "A major objective in the treatment of Alzheimer's disease is amyloid plaque reduction. Transgenic mouse models of Alzheimer's disease provide a controlled and consistent environment for studying amyloid plaque deposition in Alzheimer's disease. Magnetic resonance imaging is an attractive tool for longitudinal studies because it offers noninvasive monitoring of amyloid plaques. Recent studies have demonstrated the ability of magnetic resonance imaging to detect individual plaques in living mice. This review discusses the mouse models, MR pulse sequences, and parameters that have been used to image plaques and how they can be optimized for future studies.",
keywords = "Alzheimer's disease, Magnetic resonance imaging, Magnetic resonance micro imaging, MR microscopy, Transgenic mice",
author = "Ryan Chamberlain and Wengenack, {Thomas M.} and Poduslo, {Joseph F.} and Michael Garwood and Jack, {Clifford R Jr.}",
year = "2011",
month = "6",
doi = "10.2174/157340511794653522",
language = "English (US)",
volume = "7",
pages = "3--7",
journal = "Current Medical Imaging Reviews",
issn = "1573-4056",
publisher = "Bentham Science Publishers B.V.",
number = "1",

}

TY - JOUR

T1 - Magnetic resonance imaging of amyloid plaques in transgenic mouse models of alzheimer's disease

AU - Chamberlain, Ryan

AU - Wengenack, Thomas M.

AU - Poduslo, Joseph F.

AU - Garwood, Michael

AU - Jack, Clifford R Jr.

PY - 2011/6

Y1 - 2011/6

N2 - A major objective in the treatment of Alzheimer's disease is amyloid plaque reduction. Transgenic mouse models of Alzheimer's disease provide a controlled and consistent environment for studying amyloid plaque deposition in Alzheimer's disease. Magnetic resonance imaging is an attractive tool for longitudinal studies because it offers noninvasive monitoring of amyloid plaques. Recent studies have demonstrated the ability of magnetic resonance imaging to detect individual plaques in living mice. This review discusses the mouse models, MR pulse sequences, and parameters that have been used to image plaques and how they can be optimized for future studies.

AB - A major objective in the treatment of Alzheimer's disease is amyloid plaque reduction. Transgenic mouse models of Alzheimer's disease provide a controlled and consistent environment for studying amyloid plaque deposition in Alzheimer's disease. Magnetic resonance imaging is an attractive tool for longitudinal studies because it offers noninvasive monitoring of amyloid plaques. Recent studies have demonstrated the ability of magnetic resonance imaging to detect individual plaques in living mice. This review discusses the mouse models, MR pulse sequences, and parameters that have been used to image plaques and how they can be optimized for future studies.

KW - Alzheimer's disease

KW - Magnetic resonance imaging

KW - Magnetic resonance micro imaging

KW - MR microscopy

KW - Transgenic mice

UR - http://www.scopus.com/inward/record.url?scp=79955654586&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955654586&partnerID=8YFLogxK

U2 - 10.2174/157340511794653522

DO - 10.2174/157340511794653522

M3 - Article

AN - SCOPUS:79955654586

VL - 7

SP - 3

EP - 7

JO - Current Medical Imaging Reviews

JF - Current Medical Imaging Reviews

SN - 1573-4056

IS - 1

ER -