Magnetic resonance imaging of amyloid plaques in transgenic mouse models of alzheimer's disease

Ryan Chamberlain, Thomas M. Wengenack, Joseph F. Poduslo, Michael Garwood, Clifford R. Jack

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

A major objective in the treatment of Alzheimer's disease is amyloid plaque reduction. Transgenic mouse models of Alzheimer's disease provide a controlled and consistent environment for studying amyloid plaque deposition in Alzheimer's disease. Magnetic resonance imaging is an attractive tool for longitudinal studies because it offers noninvasive monitoring of amyloid plaques. Recent studies have demonstrated the ability of magnetic resonance imaging to detect individual plaques in living mice. This review discusses the mouse models, MR pulse sequences, and parameters that have been used to image plaques and how they can be optimized for future studies.

Original languageEnglish (US)
Pages (from-to)3-7
Number of pages5
JournalCurrent Medical Imaging Reviews
Volume7
Issue number1
DOIs
StatePublished - Jun 2011

Keywords

  • Alzheimer's disease
  • MR microscopy
  • Magnetic resonance imaging
  • Magnetic resonance micro imaging
  • Transgenic mice

ASJC Scopus subject areas

  • Internal Medicine
  • Radiology Nuclear Medicine and imaging

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