TY - JOUR
T1 - Magnetic resonance imaging in the diagnosis of acute renal allograft rejection and its differentiation from acute tubular necrosis
T2 - Experimental study in the dog
AU - Terrier, François
AU - Hricak, Hedvig
AU - Revel, Didier
AU - Alpers, J. Charles
AU - Bretan, Peter
AU - Ehman, Richard L.
AU - Feduska, Nicolas J.
PY - 1985/9
Y1 - 1985/9
N2 - This study was designed to evaluate the potential utility of magnetic resonance imaging (MRI) for the diagnosis of acute renal allograft rejection and its differentiation from acute tubular necrosis (ATN). Eighteen canines were used. Five animals served as controls. ATN was induced in six animals by cross-clamping of the left renal artery for 90 minutes. In order to study acute renal allograft rejection, seven animals were subjected to exchange allograft transplantation of the left kidney. MRI was performed with a 0.35T superconductive magnet. A double spin-echo technique was used with varying TR and TE parameters. The spin echo images were analyzed for morphology, signal intensity, T1 and T2 relaxation times, and spin density. The most useful MRI criteria for the diagnosis of ATN and acute rejection were found to be the renal size, the intensity difference between cortex and medulla (corti- comedullary contrast), and the T1 relaxation time of the cortex. Normal kidneys showed maximal corticomedullary contrast (19% + /-2) on images obtained with TR = 0.5 sec and TE = 28 msec. Cortical T1 relaxation time was 551 msec + /-73. In the ATN group, the kidneys were slightly swollen (P = ns) and the corticomedullary contrast (11% + /-3) was reduced by 42% (P<.01). T1 of the cortex (689 + /-142) was increased by 25% (P<.10). In acute rejection, significant renal enlargement was noted (P<.05). The corticomedullary contrast (9% +/-3) was diminished by 53% (P <.01) while T1 of the cortex (802 msec + /-84) was increased by 45% (P <.01). Although the changes observed in acute rejection were more severe than in ATN, they were not specific since in one case of mild rejection, findings similar to those in ATN were observed.
AB - This study was designed to evaluate the potential utility of magnetic resonance imaging (MRI) for the diagnosis of acute renal allograft rejection and its differentiation from acute tubular necrosis (ATN). Eighteen canines were used. Five animals served as controls. ATN was induced in six animals by cross-clamping of the left renal artery for 90 minutes. In order to study acute renal allograft rejection, seven animals were subjected to exchange allograft transplantation of the left kidney. MRI was performed with a 0.35T superconductive magnet. A double spin-echo technique was used with varying TR and TE parameters. The spin echo images were analyzed for morphology, signal intensity, T1 and T2 relaxation times, and spin density. The most useful MRI criteria for the diagnosis of ATN and acute rejection were found to be the renal size, the intensity difference between cortex and medulla (corti- comedullary contrast), and the T1 relaxation time of the cortex. Normal kidneys showed maximal corticomedullary contrast (19% + /-2) on images obtained with TR = 0.5 sec and TE = 28 msec. Cortical T1 relaxation time was 551 msec + /-73. In the ATN group, the kidneys were slightly swollen (P = ns) and the corticomedullary contrast (11% + /-3) was reduced by 42% (P<.01). T1 of the cortex (689 + /-142) was increased by 25% (P<.10). In acute rejection, significant renal enlargement was noted (P<.05). The corticomedullary contrast (9% +/-3) was diminished by 53% (P <.01) while T1 of the cortex (802 msec + /-84) was increased by 45% (P <.01). Although the changes observed in acute rejection were more severe than in ATN, they were not specific since in one case of mild rejection, findings similar to those in ATN were observed.
KW - Acute renal allograft rejection
KW - Acute tubular necrosis
KW - Magnetic resonance imaging
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U2 - 10.1097/00004424-198509000-00016
DO - 10.1097/00004424-198509000-00016
M3 - Article
C2 - 3905693
AN - SCOPUS:0022339551
SN - 0020-9996
VL - 20
SP - 617
EP - 625
JO - Investigative radiology
JF - Investigative radiology
IS - 6
ER -