Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2

Clifford R. Jack; Josephine Barnes; Matt A. Bernstein; Bret J. Borowski; James Brewer; Shona Clegg; Anders M. Dale; Owen Carmichael; Christopher Ching; Charles DeCarli; Rahul S. Desikan; Christine Fennema-Notestine; Anders M. Fjell; Evan Fletcher; Nick C. Fox; Jeff Gunter; Boris A. Gutman; Dominic Holland; Xue Hua; Philip Insel; Kejal Kantarci; Ron J. Killiany; Gunnar Krueger; Kelvin K. Leung; Scott Mackin; Pauline Maillard; Ian B. Malone; Niklas Mattsson; Linda McEvoy; Marc Modat; Susanne Mueller; Rachel Nosheny; Sebastien Ourselin; Norbert Schuff; Matthew L. Senjem; Alix Simonson; Paul M. Thompson; Dan Rettmann; Prashanthi Vemuri; Kristine Walhovd; Yansong Zhao; Samantha Zuk; Michael Weiner

doi:10.1016/j.jalz.2015.05.002

Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2

Clifford R. Jack, Josephine Barnes, Matt A. Bernstein, Bret J. Borowski, James Brewer, Shona Clegg, Anders M. Dale, Owen Carmichael, Christopher Ching, Charles DeCarli, Rahul S. Desikan, Christine Fennema-Notestine, Anders M. Fjell, Evan Fletcher, Nick C. Fox, Jeff Gunter, Boris A. Gutman, Dominic Holland, Xue Hua, Philip InselKejal Kantarci, Ron J. Killiany, Gunnar Krueger, Kelvin K. Leung, Scott Mackin, Pauline Maillard, Ian B. Malone, Niklas Mattsson, Linda McEvoy, Marc Modat, Susanne Mueller, Rachel Nosheny, Sebastien Ourselin, Norbert Schuff, Matthew L. Senjem, Alix Simonson, Paul M. Thompson, Dan Rettmann, Prashanthi Vemuri, Kristine Walhovd, Yansong Zhao, Samantha Zuk, Michael Weiner

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

Introduction Alzheimer's Disease Neuroimaging Initiative (ADNI) is now in its 10th year. The primary objective of the magnetic resonance imaging (MRI) core of ADNI has been to improve methods for clinical trials in Alzheimer's disease (AD) and related disorders. Methods We review the contributions of the MRI core from present and past cycles of ADNI (ADNI-1, -Grand Opportunity and -2). We also review plans for the future-ADNI-3. Results Contributions of the MRI core include creating standardized acquisition protocols and quality control methods; examining the effect of technical features of image acquisition and analysis on outcome metrics; deriving sample size estimates for future trials based on those outcomes; and piloting the potential utility of MR perfusion, diffusion, and functional connectivity measures in multicenter clinical trials. Discussion Over the past decade the MRI core of ADNI has fulfilled its mandate of improving methods for clinical trials in AD and will continue to do so in the future.

Original language	English (US)
Pages (from-to)	740-756
Number of pages	17
Journal	Alzheimer's and Dementia
Volume	11
Issue number	7
DOIs	https://doi.org/10.1016/j.jalz.2015.05.002
State	Published - Jul 1 2015

Keywords

ADNI
Alzheimer's Disease Neuroimaging Initiative
Alzheimer's disease
Diffusion
MRI
Neuroimaging
Perfusion
Resting functional MRI

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Cellular and Molecular Neuroscience
Psychiatry and Mental health

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10.1016/j.jalz.2015.05.002

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Jack, C. R., Barnes, J., Bernstein, M. A., Borowski, B. J., Brewer, J., Clegg, S., Dale, A. M., Carmichael, O., Ching, C., DeCarli, C., Desikan, R. S., Fennema-Notestine, C., Fjell, A. M., Fletcher, E., Fox, N. C., Gunter, J., Gutman, B. A., Holland, D., Hua, X., ... Weiner, M. (2015). Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2. Alzheimer's and Dementia, 11(7), 740-756. https://doi.org/10.1016/j.jalz.2015.05.002

Jack, CR, Barnes, J, Bernstein, MA, Borowski, BJ, Brewer, J, Clegg, S, Dale, AM, Carmichael, O, Ching, C, DeCarli, C, Desikan, RS, Fennema-Notestine, C, Fjell, AM, Fletcher, E, Fox, NC, Gunter, J, Gutman, BA, Holland, D, Hua, X, Insel, P, Kantarci, K, Killiany, RJ, Krueger, G, Leung, KK, Mackin, S, Maillard, P, Malone, IB, Mattsson, N, McEvoy, L, Modat, M, Mueller, S, Nosheny, R, Ourselin, S, Schuff, N, Senjem, ML, Simonson, A, Thompson, PM, Rettmann, D, Vemuri, P, Walhovd, K, Zhao, Y, Zuk, S & Weiner, M 2015, 'Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2', Alzheimer's and Dementia, vol. 11, no. 7, pp. 740-756. https://doi.org/10.1016/j.jalz.2015.05.002

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title = "Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2",

abstract = "Introduction Alzheimer's Disease Neuroimaging Initiative (ADNI) is now in its 10th year. The primary objective of the magnetic resonance imaging (MRI) core of ADNI has been to improve methods for clinical trials in Alzheimer's disease (AD) and related disorders. Methods We review the contributions of the MRI core from present and past cycles of ADNI (ADNI-1, -Grand Opportunity and -2). We also review plans for the future-ADNI-3. Results Contributions of the MRI core include creating standardized acquisition protocols and quality control methods; examining the effect of technical features of image acquisition and analysis on outcome metrics; deriving sample size estimates for future trials based on those outcomes; and piloting the potential utility of MR perfusion, diffusion, and functional connectivity measures in multicenter clinical trials. Discussion Over the past decade the MRI core of ADNI has fulfilled its mandate of improving methods for clinical trials in AD and will continue to do so in the future.",

keywords = "ADNI, Alzheimer's Disease Neuroimaging Initiative, Alzheimer's disease, Diffusion, MRI, Neuroimaging, Perfusion, Resting functional MRI",

author = "Jack, {Clifford R.} and Josephine Barnes and Bernstein, {Matt A.} and Borowski, {Bret J.} and James Brewer and Shona Clegg and Dale, {Anders M.} and Owen Carmichael and Christopher Ching and Charles DeCarli and Desikan, {Rahul S.} and Christine Fennema-Notestine and Fjell, {Anders M.} and Evan Fletcher and Fox, {Nick C.} and Jeff Gunter and Gutman, {Boris A.} and Dominic Holland and Xue Hua and Philip Insel and Kejal Kantarci and Killiany, {Ron J.} and Gunnar Krueger and Leung, {Kelvin K.} and Scott Mackin and Pauline Maillard and Malone, {Ian B.} and Niklas Mattsson and Linda McEvoy and Marc Modat and Susanne Mueller and Rachel Nosheny and Sebastien Ourselin and Norbert Schuff and Senjem, {Matthew L.} and Alix Simonson and Thompson, {Paul M.} and Dan Rettmann and Prashanthi Vemuri and Kristine Walhovd and Yansong Zhao and Samantha Zuk and Michael Weiner",

note = "Publisher Copyright: {\textcopyright} 2015 The Authors. Published by Elsevier Inc.",

year = "2015",

month = jul,

day = "1",

doi = "10.1016/j.jalz.2015.05.002",

language = "English (US)",

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T1 - Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2

AU - Jack, Clifford R.

AU - Barnes, Josephine

AU - Bernstein, Matt A.

AU - Borowski, Bret J.

AU - Brewer, James

AU - Clegg, Shona

AU - Dale, Anders M.

AU - Carmichael, Owen

AU - Ching, Christopher

AU - DeCarli, Charles

AU - Desikan, Rahul S.

AU - Fennema-Notestine, Christine

AU - Fjell, Anders M.

AU - Fletcher, Evan

AU - Fox, Nick C.

AU - Gunter, Jeff

AU - Gutman, Boris A.

AU - Holland, Dominic

AU - Hua, Xue

AU - Insel, Philip

AU - Kantarci, Kejal

AU - Killiany, Ron J.

AU - Krueger, Gunnar

AU - Leung, Kelvin K.

AU - Mackin, Scott

AU - Maillard, Pauline

AU - Malone, Ian B.

AU - Mattsson, Niklas

AU - McEvoy, Linda

AU - Modat, Marc

AU - Mueller, Susanne

AU - Nosheny, Rachel

AU - Ourselin, Sebastien

AU - Schuff, Norbert

AU - Senjem, Matthew L.

AU - Simonson, Alix

AU - Thompson, Paul M.

AU - Rettmann, Dan

AU - Vemuri, Prashanthi

AU - Walhovd, Kristine

AU - Zhao, Yansong

AU - Zuk, Samantha

AU - Weiner, Michael

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Introduction Alzheimer's Disease Neuroimaging Initiative (ADNI) is now in its 10th year. The primary objective of the magnetic resonance imaging (MRI) core of ADNI has been to improve methods for clinical trials in Alzheimer's disease (AD) and related disorders. Methods We review the contributions of the MRI core from present and past cycles of ADNI (ADNI-1, -Grand Opportunity and -2). We also review plans for the future-ADNI-3. Results Contributions of the MRI core include creating standardized acquisition protocols and quality control methods; examining the effect of technical features of image acquisition and analysis on outcome metrics; deriving sample size estimates for future trials based on those outcomes; and piloting the potential utility of MR perfusion, diffusion, and functional connectivity measures in multicenter clinical trials. Discussion Over the past decade the MRI core of ADNI has fulfilled its mandate of improving methods for clinical trials in AD and will continue to do so in the future.

AB - Introduction Alzheimer's Disease Neuroimaging Initiative (ADNI) is now in its 10th year. The primary objective of the magnetic resonance imaging (MRI) core of ADNI has been to improve methods for clinical trials in Alzheimer's disease (AD) and related disorders. Methods We review the contributions of the MRI core from present and past cycles of ADNI (ADNI-1, -Grand Opportunity and -2). We also review plans for the future-ADNI-3. Results Contributions of the MRI core include creating standardized acquisition protocols and quality control methods; examining the effect of technical features of image acquisition and analysis on outcome metrics; deriving sample size estimates for future trials based on those outcomes; and piloting the potential utility of MR perfusion, diffusion, and functional connectivity measures in multicenter clinical trials. Discussion Over the past decade the MRI core of ADNI has fulfilled its mandate of improving methods for clinical trials in AD and will continue to do so in the future.

KW - ADNI

KW - Alzheimer's Disease Neuroimaging Initiative

KW - Alzheimer's disease

KW - Diffusion

KW - MRI

KW - Neuroimaging

KW - Perfusion

KW - Resting functional MRI

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SN - 1552-5260

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EP - 756

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

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ER -

Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2

Abstract

Keywords

ASJC Scopus subject areas

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