Magnetic resonance imaging characteristics of glioblastoma multiforme: Implications for understanding glioma ontogeny

Leif Erik Bohman, Kristin Swanson, Julia L. Moore, Russ Rockne, Christopher Mandigo, Todd Hankinson, Marcela Assanah, Peter Canoll, Jeffrey N. Bruce

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background: Identifying the origin of gliomas carries important implications for advancing the treatment of these recalcitrant tumors. Recent research promotes the hypothesis of a subventricular zone (SVZ) origin for the stemlike gliomagenic cells identified within human glioma specimens. However, conflicting evidence suggests that SVZ-like cells are not uniquely gliomagenic but this capacity may be shared by cycling progenitors distributed throughout the subcortical white matter (SCWM). Objective: To review radiological evidence in glioblastoma multiforme (GBM) patients to provide insight into the question of glioma ontogeny. Methods: We explored whether GBMs at first diagnosis demonstrated a pattern of anatomic distribution consistent with origin at the SVZ through retrospective analysis of preoperative contrast-enhanced T1-weighted magnetic resonance images in 63 patients. We then examined the relationship of tumor volume, point of origin, and proximity to the ventricles using a computer model of glioma growth. Results: Fewer than half of the GBMs analyzed had contrast-enhancing portions that contacted the ventricle on preoperative imaging. A strong correlation was found between tumor volume and the distance between the contrast-enhancing edge of the tumor and the ventricle, demonstrating that tumors abutting the ventricle are significantly larger than those that do not. The lesions simulated by the computer model validated our assumption that tumors that are radiographically distant from the ventricles are unlikely to have originated in the SVZ and supported our hypothesis that as they grow, the edges of all tumors will near the ventricles, regardless of their point of origin. Conclusion: This work offers further support for the hypothesis that the origins of GBMs are at sites distributed throughout the white matter and are not limited to the region of the SVZ.

Original languageEnglish (US)
Pages (from-to)1319-1327
Number of pages9
JournalNeurosurgery
Volume67
Issue number5
DOIs
StatePublished - Nov 2010
Externally publishedYes

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Lateral Ventricles
Glioblastoma
Glioma
Magnetic Resonance Imaging
Neoplasms
Tumor Burden
Computer Simulation
Magnetic Resonance Spectroscopy
Growth
Research
White Matter

Keywords

  • Cancer stem cell
  • Glioblastoma
  • Glioma
  • Glioma ontogeny

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Magnetic resonance imaging characteristics of glioblastoma multiforme : Implications for understanding glioma ontogeny. / Bohman, Leif Erik; Swanson, Kristin; Moore, Julia L.; Rockne, Russ; Mandigo, Christopher; Hankinson, Todd; Assanah, Marcela; Canoll, Peter; Bruce, Jeffrey N.

In: Neurosurgery, Vol. 67, No. 5, 11.2010, p. 1319-1327.

Research output: Contribution to journalArticle

Bohman, LE, Swanson, K, Moore, JL, Rockne, R, Mandigo, C, Hankinson, T, Assanah, M, Canoll, P & Bruce, JN 2010, 'Magnetic resonance imaging characteristics of glioblastoma multiforme: Implications for understanding glioma ontogeny', Neurosurgery, vol. 67, no. 5, pp. 1319-1327. https://doi.org/10.1227/NEU.0b013e3181f556ab
Bohman, Leif Erik ; Swanson, Kristin ; Moore, Julia L. ; Rockne, Russ ; Mandigo, Christopher ; Hankinson, Todd ; Assanah, Marcela ; Canoll, Peter ; Bruce, Jeffrey N. / Magnetic resonance imaging characteristics of glioblastoma multiforme : Implications for understanding glioma ontogeny. In: Neurosurgery. 2010 ; Vol. 67, No. 5. pp. 1319-1327.
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