Abstract
We performed a prospective study correlating magnetic resonance imaging volume measurements of the hippocampal formation with histopathology in 24 patients with intractable partial epilepsy who subsequently underwent an anterior temporal lobectomy for their seizure disorder. Patients with mass lesions verified pathologically were excluded from this study. In 71% of patients, quantitative hippocampal formation atrophy correctly lateralized the temporal lobe of seizure origin; in 29%, the volume study was indeterminant. The severity of the pathological alterations in the hippocampus correlated with the hippocampal formation volume determination. Mesial temporal sclerosis was identified in the surgically excised temporal lobe in 15 patients. The magnetic resonance imaging volume studies indicated hippocampal atrophy in the temporal lobe resected in 14 of the 15 patients. Magnetic resonance imaging-based volume measurements of the hippocampal formation increase the diagnostic yield of magnetic resonance imaging scanning in patients with intractable partial epilepsy related to mesial temporal sclerosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 31-36 |
| Number of pages | 6 |
| Journal | Annals of Neurology |
| Volume | 30 |
| Issue number | 1 |
| State | Published - 1991 |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Magnetic resonance imaging-based volume studies in temporal lobe epilepsy : Pathological correlations. / Cascino, Gregory D; Jack, Clifford R Jr.; Parisi, Joseph E; Sharbrough, F. W.; Hirschorn, K. A.; Meyer, F. B.; Marsh, W. R.; O'Brien, P. C.
In: Annals of Neurology, Vol. 30, No. 1, 1991, p. 31-36.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Magnetic resonance imaging-based volume studies in temporal lobe epilepsy
T2 - Pathological correlations
AU - Cascino, Gregory D
AU - Jack, Clifford R Jr.
AU - Parisi, Joseph E
AU - Sharbrough, F. W.
AU - Hirschorn, K. A.
AU - Meyer, F. B.
AU - Marsh, W. R.
AU - O'Brien, P. C.
PY - 1991
Y1 - 1991
N2 - We performed a prospective study correlating magnetic resonance imaging volume measurements of the hippocampal formation with histopathology in 24 patients with intractable partial epilepsy who subsequently underwent an anterior temporal lobectomy for their seizure disorder. Patients with mass lesions verified pathologically were excluded from this study. In 71% of patients, quantitative hippocampal formation atrophy correctly lateralized the temporal lobe of seizure origin; in 29%, the volume study was indeterminant. The severity of the pathological alterations in the hippocampus correlated with the hippocampal formation volume determination. Mesial temporal sclerosis was identified in the surgically excised temporal lobe in 15 patients. The magnetic resonance imaging volume studies indicated hippocampal atrophy in the temporal lobe resected in 14 of the 15 patients. Magnetic resonance imaging-based volume measurements of the hippocampal formation increase the diagnostic yield of magnetic resonance imaging scanning in patients with intractable partial epilepsy related to mesial temporal sclerosis.
AB - We performed a prospective study correlating magnetic resonance imaging volume measurements of the hippocampal formation with histopathology in 24 patients with intractable partial epilepsy who subsequently underwent an anterior temporal lobectomy for their seizure disorder. Patients with mass lesions verified pathologically were excluded from this study. In 71% of patients, quantitative hippocampal formation atrophy correctly lateralized the temporal lobe of seizure origin; in 29%, the volume study was indeterminant. The severity of the pathological alterations in the hippocampus correlated with the hippocampal formation volume determination. Mesial temporal sclerosis was identified in the surgically excised temporal lobe in 15 patients. The magnetic resonance imaging volume studies indicated hippocampal atrophy in the temporal lobe resected in 14 of the 15 patients. Magnetic resonance imaging-based volume measurements of the hippocampal formation increase the diagnostic yield of magnetic resonance imaging scanning in patients with intractable partial epilepsy related to mesial temporal sclerosis.
UR - http://www.scopus.com/inward/record.url?scp=0025730269&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025730269&partnerID=8YFLogxK
M3 - Article
VL - 30
SP - 31
EP - 36
JO - Annals of Neurology
JF - Annals of Neurology
SN - 0364-5134
IS - 1
ER -