Magnetic resonance imaging-based volume studies in temporal lobe epilepsy

Pathological correlations

Gregory D Cascino, Clifford R Jr. Jack, Joseph E Parisi, F. W. Sharbrough, K. A. Hirschorn, F. B. Meyer, W. R. Marsh, P. C. O'Brien

Research output: Contribution to journalArticle

392 Citations (Scopus)

Abstract

We performed a prospective study correlating magnetic resonance imaging volume measurements of the hippocampal formation with histopathology in 24 patients with intractable partial epilepsy who subsequently underwent an anterior temporal lobectomy for their seizure disorder. Patients with mass lesions verified pathologically were excluded from this study. In 71% of patients, quantitative hippocampal formation atrophy correctly lateralized the temporal lobe of seizure origin; in 29%, the volume study was indeterminant. The severity of the pathological alterations in the hippocampus correlated with the hippocampal formation volume determination. Mesial temporal sclerosis was identified in the surgically excised temporal lobe in 15 patients. The magnetic resonance imaging volume studies indicated hippocampal atrophy in the temporal lobe resected in 14 of the 15 patients. Magnetic resonance imaging-based volume measurements of the hippocampal formation increase the diagnostic yield of magnetic resonance imaging scanning in patients with intractable partial epilepsy related to mesial temporal sclerosis.

Original languageEnglish (US)
Pages (from-to)31-36
Number of pages6
JournalAnnals of Neurology
Volume30
Issue number1
StatePublished - 1991

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Temporal Lobe Epilepsy
Magnetic Resonance Imaging
Hippocampus
Temporal Lobe
Partial Epilepsy
Sclerosis
Atrophy
Anterior Temporal Lobectomy
Epilepsy
Seizures
Prospective Studies

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cascino, G. D., Jack, C. R. J., Parisi, J. E., Sharbrough, F. W., Hirschorn, K. A., Meyer, F. B., ... O'Brien, P. C. (1991). Magnetic resonance imaging-based volume studies in temporal lobe epilepsy: Pathological correlations. Annals of Neurology, 30(1), 31-36.

Magnetic resonance imaging-based volume studies in temporal lobe epilepsy : Pathological correlations. / Cascino, Gregory D; Jack, Clifford R Jr.; Parisi, Joseph E; Sharbrough, F. W.; Hirschorn, K. A.; Meyer, F. B.; Marsh, W. R.; O'Brien, P. C.

In: Annals of Neurology, Vol. 30, No. 1, 1991, p. 31-36.

Research output: Contribution to journalArticle

Cascino, GD, Jack, CRJ, Parisi, JE, Sharbrough, FW, Hirschorn, KA, Meyer, FB, Marsh, WR & O'Brien, PC 1991, 'Magnetic resonance imaging-based volume studies in temporal lobe epilepsy: Pathological correlations', Annals of Neurology, vol. 30, no. 1, pp. 31-36.
Cascino, Gregory D ; Jack, Clifford R Jr. ; Parisi, Joseph E ; Sharbrough, F. W. ; Hirschorn, K. A. ; Meyer, F. B. ; Marsh, W. R. ; O'Brien, P. C. / Magnetic resonance imaging-based volume studies in temporal lobe epilepsy : Pathological correlations. In: Annals of Neurology. 1991 ; Vol. 30, No. 1. pp. 31-36.
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