Magnetic resonance image-guided transcatheter closure of atrial septal defects

Carsten Rickers, Michael Jerosch-Herold, Xudong Hu, Naveen S Murthy, Xiaoen Wang, Huafu Kong, Ravi Teja Seethamraju, Jochen Weil, Norbert M. Wilke

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Background - Recent developments in cardiac MRI have extended the potential spectrum of diagnostic and interventional applications. The purpose of this study was to test the ability of MRI to perform transcatheter closures of secundum type atrial septal defects (ASD) and to assess ASD size and changes in right cardiac chamber volumes in the same investigation. Methods and Results - In 7 domestic swine (body weight, 38±13 kg), an ASD (Qp:Qs = 1.7±0.2) was created percutaneously by balloon dilation of the fossa ovalis. The ASD was imaged and sized by both conventional radiography and MRI. High-resolution MRI of the ASD diameters correlated well with postmortem examination (r=0.97). Under real-time MR fluoroscopy, the introducer sheath was tracked toward the left atrium with the use of novel miniature MR guide wires. The defect was then closed with an Amplatzer Septal Occluder. In all animals, it was possible to track and interactively control the position of the guide wire within the vessels and the heart, including the successful deployment of the Amplatzer Septal Occluder. Right atrial and ventricular volumes were calculated before and after the intervention by using cine-MRI. Both volumes were found to be significantly reduced after ASD closure (P

Original languageEnglish (US)
Pages (from-to)132-138
Number of pages7
JournalCirculation
Volume107
Issue number1
DOIs
StatePublished - Jan 7 2003
Externally publishedYes

Fingerprint

Atrial Heart Septal Defects
Magnetic Resonance Spectroscopy
Septal Occluder Device
Cine Magnetic Resonance Imaging
Cardiac Volume
Fluoroscopy
Heart Atria
Radiography
Dilatation
Autopsy
Swine
Body Weight

Keywords

  • Congenital
  • Heart defects
  • Magnetic resonance imaging
  • Pediatrics

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Rickers, C., Jerosch-Herold, M., Hu, X., Murthy, N. S., Wang, X., Kong, H., ... Wilke, N. M. (2003). Magnetic resonance image-guided transcatheter closure of atrial septal defects. Circulation, 107(1), 132-138. https://doi.org/10.1161/01.CIR.0000039343.95540.CF

Magnetic resonance image-guided transcatheter closure of atrial septal defects. / Rickers, Carsten; Jerosch-Herold, Michael; Hu, Xudong; Murthy, Naveen S; Wang, Xiaoen; Kong, Huafu; Seethamraju, Ravi Teja; Weil, Jochen; Wilke, Norbert M.

In: Circulation, Vol. 107, No. 1, 07.01.2003, p. 132-138.

Research output: Contribution to journalArticle

Rickers, C, Jerosch-Herold, M, Hu, X, Murthy, NS, Wang, X, Kong, H, Seethamraju, RT, Weil, J & Wilke, NM 2003, 'Magnetic resonance image-guided transcatheter closure of atrial septal defects', Circulation, vol. 107, no. 1, pp. 132-138. https://doi.org/10.1161/01.CIR.0000039343.95540.CF
Rickers, Carsten ; Jerosch-Herold, Michael ; Hu, Xudong ; Murthy, Naveen S ; Wang, Xiaoen ; Kong, Huafu ; Seethamraju, Ravi Teja ; Weil, Jochen ; Wilke, Norbert M. / Magnetic resonance image-guided transcatheter closure of atrial septal defects. In: Circulation. 2003 ; Vol. 107, No. 1. pp. 132-138.
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