Magnetic resonance elastography of the liver: Preliminary results and estimation of inter-rater reliability

Utaroh Motosugi, Tomoaki Ichikawa, Katsuhiro Sano, Hironobu Sou, Ali Muhi, Tsuyota Koshiishi, Richard L. Ehman, Tsutomu Araki

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Purpose: The aim of this study was to estimate inter-rater reliability and validate magnetic resonance elastography (MRE) as a tool to measure liver elasticity. Materials and methods: The study protocol was approved by the institutional review board at our institution. In all, 10 normal volunteers and 110 patients, who provided written informed consent, were enrolled. The pathological fibrosis score was applied as a standard reference of liver fibrosis in 21 patients. MRE was performed with a 1.5-T magnetic resonance imaging scanner with a cylindrical passive longitudinal shear wave driver placed over the right chest wall to deliver vibrations. A gradient-echo MRE sequence was used to acquire axial wave images, which were automatically converted to elastograms representing elasticity (in kilopascals, or kPa). The region of interest was placed in the right lobe of the liver on elastograms by two raters independently. To evaluate interrater reliability, the intraclass correlation coefficient was calculated. The elasticity measurements correlated with the pathological fibrosis score (F1-F4) in 21 patients. Results: The intraclass correlation coefficient was almost perfect (0.993) between the elasticities measured by the two raters. The mean elasticity value for patients with F4 was 5.7 kPa; F3, 4.4 kPa; F2, 3.1 kPa; F1, 2.2 kPa; and F0, 2.1 kPa. Conclusion: MRE is a reliable tool to measure liver elasticity.

Original languageEnglish (US)
Pages (from-to)623-627
Number of pages5
JournalJapanese Journal of Radiology
Issue number8
StatePublished - Oct 2010


  • Elastography
  • Fibrosis
  • Liver
  • MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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