Magnetic resonance elastography of the brain in a mouse model of Alzheimer's disease: Initial results

Matthew C. Murphy; Geoffrey L. Curran; Kevin J. Glaser; Phillip J. Rossman; John Huston; Joseph F. Poduslo; Clifford R. Jack; Joel P. Felmlee; Richard L. Ehman

doi:10.1016/j.mri.2011.12.019

Magnetic resonance elastography of the brain in a mouse model of Alzheimer's disease: Initial results

Matthew C. Murphy, Geoffrey L. Curran, Kevin J. Glaser, Phillip J. Rossman, John Huston, Joseph F. Poduslo, Clifford R. Jack, Joel P. Felmlee, Richard L. Ehman

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

The increasing prevalence of Alzheimer's disease (AD) has provided motivation for developing novel methods for assessing the disease and the effects of potential treatments. Magnetic resonance elastography (MRE) is an MRI-based method for quantitatively imaging the shear tissue stiffness in vivo. The objective of this research was to determine whether this new imaging biomarker has potential for characterizing neurodegenerative disease. Methods were developed and tested for applying MRE to evaluate the mouse brain, using a conventional large bore 3.0T MRI system. The technique was then applied to study APP-PS1 mice, a well-characterized model of AD. Five APP-PS1 mice and 8 age-matched wild-type mice were imaged immediately following sacrifice. Brain shear stiffness measurements in APP-PS1 mice averaged 22.5% lower than those for wild-type mice (P = .0031). The results indicate that mouse brain MRE is feasible at 3.0T, and brain shear stiffness has merit for further investigation as a potential new biomarker for Alzheimer's disease.

Original language	English (US)
Pages (from-to)	535-539
Number of pages	5
Journal	Magnetic Resonance Imaging
Volume	30
Issue number	4
DOIs	https://doi.org/10.1016/j.mri.2011.12.019
State	Published - May 2012

Keywords

APP-PS1
Alzheimer's disease
Brain
MR elastography
Stiffness

ASJC Scopus subject areas

Biophysics
Biomedical Engineering
Radiology Nuclear Medicine and imaging

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10.1016/j.mri.2011.12.019

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title = "Magnetic resonance elastography of the brain in a mouse model of Alzheimer's disease: Initial results",

abstract = "The increasing prevalence of Alzheimer's disease (AD) has provided motivation for developing novel methods for assessing the disease and the effects of potential treatments. Magnetic resonance elastography (MRE) is an MRI-based method for quantitatively imaging the shear tissue stiffness in vivo. The objective of this research was to determine whether this new imaging biomarker has potential for characterizing neurodegenerative disease. Methods were developed and tested for applying MRE to evaluate the mouse brain, using a conventional large bore 3.0T MRI system. The technique was then applied to study APP-PS1 mice, a well-characterized model of AD. Five APP-PS1 mice and 8 age-matched wild-type mice were imaged immediately following sacrifice. Brain shear stiffness measurements in APP-PS1 mice averaged 22.5% lower than those for wild-type mice (P = .0031). The results indicate that mouse brain MRE is feasible at 3.0T, and brain shear stiffness has merit for further investigation as a potential new biomarker for Alzheimer's disease.",

keywords = "APP-PS1, Alzheimer's disease, Brain, MR elastography, Stiffness",

author = "Murphy, {Matthew C.} and Curran, {Geoffrey L.} and Glaser, {Kevin J.} and Rossman, {Phillip J.} and John Huston and Poduslo, {Joseph F.} and Jack, {Clifford R.} and Felmlee, {Joel P.} and Ehman, {Richard L.}",

note = "Funding Information: This work was supported by NIH R01 grants EB001981 and AG11378.",

year = "2012",

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doi = "10.1016/j.mri.2011.12.019",

language = "English (US)",

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AU - Murphy, Matthew C.

AU - Curran, Geoffrey L.

AU - Glaser, Kevin J.

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AU - Huston, John

AU - Poduslo, Joseph F.

AU - Jack, Clifford R.

AU - Felmlee, Joel P.

AU - Ehman, Richard L.

N1 - Funding Information: This work was supported by NIH R01 grants EB001981 and AG11378.

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N2 - The increasing prevalence of Alzheimer's disease (AD) has provided motivation for developing novel methods for assessing the disease and the effects of potential treatments. Magnetic resonance elastography (MRE) is an MRI-based method for quantitatively imaging the shear tissue stiffness in vivo. The objective of this research was to determine whether this new imaging biomarker has potential for characterizing neurodegenerative disease. Methods were developed and tested for applying MRE to evaluate the mouse brain, using a conventional large bore 3.0T MRI system. The technique was then applied to study APP-PS1 mice, a well-characterized model of AD. Five APP-PS1 mice and 8 age-matched wild-type mice were imaged immediately following sacrifice. Brain shear stiffness measurements in APP-PS1 mice averaged 22.5% lower than those for wild-type mice (P = .0031). The results indicate that mouse brain MRE is feasible at 3.0T, and brain shear stiffness has merit for further investigation as a potential new biomarker for Alzheimer's disease.

AB - The increasing prevalence of Alzheimer's disease (AD) has provided motivation for developing novel methods for assessing the disease and the effects of potential treatments. Magnetic resonance elastography (MRE) is an MRI-based method for quantitatively imaging the shear tissue stiffness in vivo. The objective of this research was to determine whether this new imaging biomarker has potential for characterizing neurodegenerative disease. Methods were developed and tested for applying MRE to evaluate the mouse brain, using a conventional large bore 3.0T MRI system. The technique was then applied to study APP-PS1 mice, a well-characterized model of AD. Five APP-PS1 mice and 8 age-matched wild-type mice were imaged immediately following sacrifice. Brain shear stiffness measurements in APP-PS1 mice averaged 22.5% lower than those for wild-type mice (P = .0031). The results indicate that mouse brain MRE is feasible at 3.0T, and brain shear stiffness has merit for further investigation as a potential new biomarker for Alzheimer's disease.

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Magnetic resonance elastography of the brain in a mouse model of Alzheimer's disease: Initial results

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Keywords

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