Magnetic resonance elastography of skeletal muscle

M. Alex Dresner, Gregory H. Rose, Phillip J. Rossman, Raja Muthupillai, Armando Manduca, Richard Lorne Ehman

Research output: Contribution to journalArticle

201 Citations (Scopus)

Abstract

While the contractile properties of skeletal muscle have been studied extensively, relatively little is known about the elastic properties of muscle in vivo. Magnetic resonance elastography (MRE) is a phase contrast-based method for observing shear waves propagating in a material to determine its stiffness. In this work, MHE is applied to skeletal muscle under load to quantify the change in stiffness with loading. A mathematical model of muscle is developed that predicts a linear relationship between shear stiffness and muscle load. The MRE technique was applied to bovine muscle specimens (N = 10) and human biceps brachii in vivo (N = 5). Muscle stiffness increased linearly for both passive tension (14.5 ± 1.77 kPa/kg) and active tension, in which the increase in stiffness was dependent upon muscle size, as predicted by the model. A means of noninvasively assessing the viscoelastic properties of skeletal muscle in vivo may provide a useful method for studying muscle biomechanics in health and disease. J. Magn. Reson. Imaging 2001;13:269-276.

Original languageEnglish (US)
Pages (from-to)269-276
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume13
Issue number2
DOIs
StatePublished - 2001

Fingerprint

Elasticity Imaging Techniques
Skeletal Muscle
Muscles
Biomechanical Phenomena
Theoretical Models
Health

Keywords

  • Contraction
  • Elastography
  • Magnetic resonance imaging
  • Mechanical properties
  • Muscle

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Magnetic resonance elastography of skeletal muscle. / Alex Dresner, M.; Rose, Gregory H.; Rossman, Phillip J.; Muthupillai, Raja; Manduca, Armando; Ehman, Richard Lorne.

In: Journal of Magnetic Resonance Imaging, Vol. 13, No. 2, 2001, p. 269-276.

Research output: Contribution to journalArticle

Alex Dresner, M. ; Rose, Gregory H. ; Rossman, Phillip J. ; Muthupillai, Raja ; Manduca, Armando ; Ehman, Richard Lorne. / Magnetic resonance elastography of skeletal muscle. In: Journal of Magnetic Resonance Imaging. 2001 ; Vol. 13, No. 2. pp. 269-276.
@article{a640d817aba64133b85efe923631d432,
title = "Magnetic resonance elastography of skeletal muscle",
abstract = "While the contractile properties of skeletal muscle have been studied extensively, relatively little is known about the elastic properties of muscle in vivo. Magnetic resonance elastography (MRE) is a phase contrast-based method for observing shear waves propagating in a material to determine its stiffness. In this work, MHE is applied to skeletal muscle under load to quantify the change in stiffness with loading. A mathematical model of muscle is developed that predicts a linear relationship between shear stiffness and muscle load. The MRE technique was applied to bovine muscle specimens (N = 10) and human biceps brachii in vivo (N = 5). Muscle stiffness increased linearly for both passive tension (14.5 ± 1.77 kPa/kg) and active tension, in which the increase in stiffness was dependent upon muscle size, as predicted by the model. A means of noninvasively assessing the viscoelastic properties of skeletal muscle in vivo may provide a useful method for studying muscle biomechanics in health and disease. J. Magn. Reson. Imaging 2001;13:269-276.",
keywords = "Contraction, Elastography, Magnetic resonance imaging, Mechanical properties, Muscle",
author = "{Alex Dresner}, M. and Rose, {Gregory H.} and Rossman, {Phillip J.} and Raja Muthupillai and Armando Manduca and Ehman, {Richard Lorne}",
year = "2001",
doi = "10.1002/1522-2586(200102)13:2<269::AID-JMRI1039>3.0.CO;2-1",
language = "English (US)",
volume = "13",
pages = "269--276",
journal = "Journal of Magnetic Resonance Imaging",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - Magnetic resonance elastography of skeletal muscle

AU - Alex Dresner, M.

AU - Rose, Gregory H.

AU - Rossman, Phillip J.

AU - Muthupillai, Raja

AU - Manduca, Armando

AU - Ehman, Richard Lorne

PY - 2001

Y1 - 2001

N2 - While the contractile properties of skeletal muscle have been studied extensively, relatively little is known about the elastic properties of muscle in vivo. Magnetic resonance elastography (MRE) is a phase contrast-based method for observing shear waves propagating in a material to determine its stiffness. In this work, MHE is applied to skeletal muscle under load to quantify the change in stiffness with loading. A mathematical model of muscle is developed that predicts a linear relationship between shear stiffness and muscle load. The MRE technique was applied to bovine muscle specimens (N = 10) and human biceps brachii in vivo (N = 5). Muscle stiffness increased linearly for both passive tension (14.5 ± 1.77 kPa/kg) and active tension, in which the increase in stiffness was dependent upon muscle size, as predicted by the model. A means of noninvasively assessing the viscoelastic properties of skeletal muscle in vivo may provide a useful method for studying muscle biomechanics in health and disease. J. Magn. Reson. Imaging 2001;13:269-276.

AB - While the contractile properties of skeletal muscle have been studied extensively, relatively little is known about the elastic properties of muscle in vivo. Magnetic resonance elastography (MRE) is a phase contrast-based method for observing shear waves propagating in a material to determine its stiffness. In this work, MHE is applied to skeletal muscle under load to quantify the change in stiffness with loading. A mathematical model of muscle is developed that predicts a linear relationship between shear stiffness and muscle load. The MRE technique was applied to bovine muscle specimens (N = 10) and human biceps brachii in vivo (N = 5). Muscle stiffness increased linearly for both passive tension (14.5 ± 1.77 kPa/kg) and active tension, in which the increase in stiffness was dependent upon muscle size, as predicted by the model. A means of noninvasively assessing the viscoelastic properties of skeletal muscle in vivo may provide a useful method for studying muscle biomechanics in health and disease. J. Magn. Reson. Imaging 2001;13:269-276.

KW - Contraction

KW - Elastography

KW - Magnetic resonance imaging

KW - Mechanical properties

KW - Muscle

UR - http://www.scopus.com/inward/record.url?scp=0035152684&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035152684&partnerID=8YFLogxK

U2 - 10.1002/1522-2586(200102)13:2<269::AID-JMRI1039>3.0.CO;2-1

DO - 10.1002/1522-2586(200102)13:2<269::AID-JMRI1039>3.0.CO;2-1

M3 - Article

VL - 13

SP - 269

EP - 276

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

IS - 2

ER -