Magnetic resonance elastography for the detection and staging of liver fibrosis in chronic hepatitis B

Sudhakar Kundapur Venkatesh, Gang Wang, Seng Gee Lim, Aileen Wee

Research output: Contribution to journalArticlepeer-review

111 Scopus citations

Abstract

Objectives: We measured the accuracy of magnetic resonance elastography (MRE) for the detection and staging of liver fibrosis in chronic hepatitis B (CHB) and compared it with serum fibrosis markers. Methods: Prospective comparison of MRE and routine serum fibrosis markers, namely serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST), ALT/AST ratio (AAR), AST to platelet ratio index (APRI) and prothrombin index (PI), was performed in 63 consecutive CHB patients who underwent MRE and histological confirmation of liver fibrosis within a 6-month interval. Diagnostic performance of MRE and serum markers for staging fibrosis (≥F1), significant fibrosis (≥F2), advanced fibrosis (≥F3) and cirrhosis (F4) was compared. Results: The study group comprised 63 patients (19 female; mean age±SD, 50±11.9 years). MRE (ρ = 0.94, P <0.0001), APRI (ρ = 0.42, P =0.0006), PI (ρ = 0.42, P =0.0006) and AST (ρ = 0.28, P =0.028) results correlated significantly with fibrosis stage. MRE was significantlymore accurate than serum fibrosis markers for the detection of significant fibrosis (0.99 vs. 0.55- 0.73) and cirrhosis (0.98 vs. 0.53-0.77). Sensitivity, specificity, positive predictive and negative predictive values for MRE for significant fibrosis and cirrhosis were 97.4%, 100%, 100% and 96%, and 100%, 95.2%, 91.3% and 100%, respectively. Conclusion: MRE is an accurate non-invasive technique for the detection and staging of liver fibrosis in CHB. Key Points: • Magnetic resonance elastography is accurate for liver fibrosis detection and staging. • MR elastography is more accurate than serum tests for staging liver fibrosis. • MR elastography can potentially replace liver biopsy in chronic hepatitis B.

Original languageEnglish (US)
Pages (from-to)70-78
Number of pages9
JournalEuropean radiology
Volume24
Issue number1
DOIs
StatePublished - Jan 1 2014

Keywords

  • Chronic hepatitis B
  • Cirrhosis
  • Fibrosis
  • Magnetic resonance elastography
  • Serum markers

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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