Magnetic resonance elastography: evaluation of new inversion algorithm and quantitative analysis method

Annelise M. Silva, Roger C. Grimm, Kevin J. Glaser, Yinlin Fu, Teresa Wu, Richard Lorne Ehman, Alvin C Silva

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Purpose: To assess mean shear hepatic stiffness calculations using various region of interest (ROI) techniques, a new inversion algorithm, and a confidence threshold mask. Methods: Seventy-three patients (49 with abnormal liver function tests/known chronic liver disease and 24 healthy liver transplant donors) underwent liver biopsy and magnetic resonance elastography (MRE). MRE data processed with the current inversion algorithm [multiscale direct inversion (MSDI)] was assessed using 2 ROI methods (single vs. triple). The data were then reprocessed using the new inversion algorithm (multimodel direct inversion [MMDI]) Hepatic stiffness calculations were performed using a single (70%) ROI method, with/without a 95% confidence threshold mask, and compared with MSDI. Results: For MSDI, average stiffness difference between single and triple ROI methods was not statistically significant by the 2-sample t test [0.15 kilopascals (kPa); P = .77]. For the 2 algorithms, there was little difference in average stiffness measurements of MSDI and MMDI (mean, 0.32 kPa; 9%) using a confidence mask with good agreement [intraclass correlation coefficient (ICC), 0.986 (95% CI 0.975–0.994)]. Use of the confidence mask showed excellent consistency and less variance [ICC, 0.995 (95% CI 0.993–0.998)] compared to either the inter-observer or intra-observer freehand technique. Conclusion: MRE analysis showed no significant difference between the 2 freehand ROI techniques. With a 9% average kPa variance, stiffness measurements for MSDI and MMDI were also not significantly different. The use of the confidence mask reduces calculated stiffness variability, which impacts the use of MRE for assessing therapy response and initial/longitudinal assessment of chronic liver disease.

Original languageEnglish (US)
Pages (from-to)810-817
Number of pages8
JournalAbdominal Imaging
Volume40
Issue number4
DOIs
StatePublished - Apr 1 2015

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Elasticity Imaging Techniques
Masks
Liver
Liver Diseases
Chronic Disease
Liver Function Tests
Tissue Donors
Biopsy

Keywords

  • Cirrhosis
  • Liver donor
  • Liver elastography
  • Magnetic resonance elastography
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Gastroenterology
  • Urology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Magnetic resonance elastography : evaluation of new inversion algorithm and quantitative analysis method. / Silva, Annelise M.; Grimm, Roger C.; Glaser, Kevin J.; Fu, Yinlin; Wu, Teresa; Ehman, Richard Lorne; Silva, Alvin C.

In: Abdominal Imaging, Vol. 40, No. 4, 01.04.2015, p. 810-817.

Research output: Contribution to journalArticle

Silva, Annelise M. ; Grimm, Roger C. ; Glaser, Kevin J. ; Fu, Yinlin ; Wu, Teresa ; Ehman, Richard Lorne ; Silva, Alvin C. / Magnetic resonance elastography : evaluation of new inversion algorithm and quantitative analysis method. In: Abdominal Imaging. 2015 ; Vol. 40, No. 4. pp. 810-817.
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abstract = "Purpose: To assess mean shear hepatic stiffness calculations using various region of interest (ROI) techniques, a new inversion algorithm, and a confidence threshold mask. Methods: Seventy-three patients (49 with abnormal liver function tests/known chronic liver disease and 24 healthy liver transplant donors) underwent liver biopsy and magnetic resonance elastography (MRE). MRE data processed with the current inversion algorithm [multiscale direct inversion (MSDI)] was assessed using 2 ROI methods (single vs. triple). The data were then reprocessed using the new inversion algorithm (multimodel direct inversion [MMDI]) Hepatic stiffness calculations were performed using a single (70{\%}) ROI method, with/without a 95{\%} confidence threshold mask, and compared with MSDI. Results: For MSDI, average stiffness difference between single and triple ROI methods was not statistically significant by the 2-sample t test [0.15 kilopascals (kPa); P = .77]. For the 2 algorithms, there was little difference in average stiffness measurements of MSDI and MMDI (mean, 0.32 kPa; 9{\%}) using a confidence mask with good agreement [intraclass correlation coefficient (ICC), 0.986 (95{\%} CI 0.975–0.994)]. Use of the confidence mask showed excellent consistency and less variance [ICC, 0.995 (95{\%} CI 0.993–0.998)] compared to either the inter-observer or intra-observer freehand technique. Conclusion: MRE analysis showed no significant difference between the 2 freehand ROI techniques. With a 9{\%} average kPa variance, stiffness measurements for MSDI and MMDI were also not significantly different. The use of the confidence mask reduces calculated stiffness variability, which impacts the use of MRE for assessing therapy response and initial/longitudinal assessment of chronic liver disease.",
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AU - Silva, Annelise M.

AU - Grimm, Roger C.

AU - Glaser, Kevin J.

AU - Fu, Yinlin

AU - Wu, Teresa

AU - Ehman, Richard Lorne

AU - Silva, Alvin C

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N2 - Purpose: To assess mean shear hepatic stiffness calculations using various region of interest (ROI) techniques, a new inversion algorithm, and a confidence threshold mask. Methods: Seventy-three patients (49 with abnormal liver function tests/known chronic liver disease and 24 healthy liver transplant donors) underwent liver biopsy and magnetic resonance elastography (MRE). MRE data processed with the current inversion algorithm [multiscale direct inversion (MSDI)] was assessed using 2 ROI methods (single vs. triple). The data were then reprocessed using the new inversion algorithm (multimodel direct inversion [MMDI]) Hepatic stiffness calculations were performed using a single (70%) ROI method, with/without a 95% confidence threshold mask, and compared with MSDI. Results: For MSDI, average stiffness difference between single and triple ROI methods was not statistically significant by the 2-sample t test [0.15 kilopascals (kPa); P = .77]. For the 2 algorithms, there was little difference in average stiffness measurements of MSDI and MMDI (mean, 0.32 kPa; 9%) using a confidence mask with good agreement [intraclass correlation coefficient (ICC), 0.986 (95% CI 0.975–0.994)]. Use of the confidence mask showed excellent consistency and less variance [ICC, 0.995 (95% CI 0.993–0.998)] compared to either the inter-observer or intra-observer freehand technique. Conclusion: MRE analysis showed no significant difference between the 2 freehand ROI techniques. With a 9% average kPa variance, stiffness measurements for MSDI and MMDI were also not significantly different. The use of the confidence mask reduces calculated stiffness variability, which impacts the use of MRE for assessing therapy response and initial/longitudinal assessment of chronic liver disease.

AB - Purpose: To assess mean shear hepatic stiffness calculations using various region of interest (ROI) techniques, a new inversion algorithm, and a confidence threshold mask. Methods: Seventy-three patients (49 with abnormal liver function tests/known chronic liver disease and 24 healthy liver transplant donors) underwent liver biopsy and magnetic resonance elastography (MRE). MRE data processed with the current inversion algorithm [multiscale direct inversion (MSDI)] was assessed using 2 ROI methods (single vs. triple). The data were then reprocessed using the new inversion algorithm (multimodel direct inversion [MMDI]) Hepatic stiffness calculations were performed using a single (70%) ROI method, with/without a 95% confidence threshold mask, and compared with MSDI. Results: For MSDI, average stiffness difference between single and triple ROI methods was not statistically significant by the 2-sample t test [0.15 kilopascals (kPa); P = .77]. For the 2 algorithms, there was little difference in average stiffness measurements of MSDI and MMDI (mean, 0.32 kPa; 9%) using a confidence mask with good agreement [intraclass correlation coefficient (ICC), 0.986 (95% CI 0.975–0.994)]. Use of the confidence mask showed excellent consistency and less variance [ICC, 0.995 (95% CI 0.993–0.998)] compared to either the inter-observer or intra-observer freehand technique. Conclusion: MRE analysis showed no significant difference between the 2 freehand ROI techniques. With a 9% average kPa variance, stiffness measurements for MSDI and MMDI were also not significantly different. The use of the confidence mask reduces calculated stiffness variability, which impacts the use of MRE for assessing therapy response and initial/longitudinal assessment of chronic liver disease.

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KW - Liver donor

KW - Liver elastography

KW - Magnetic resonance elastography

KW - Magnetic resonance imaging

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