@inproceedings{b1465952545742a0b484e68f74ede2f0,
title = "Magnetic resonance elastography assesment of focused ultrasound surgery in cancer models - A pilot study",
abstract = "MRI guided focused ultrasound (FUS) has been shown to create thermal lesions where tissue stiffness changes significantly. To assess the correlation between tissue stiffness change and tissue ablation, a pilot animal based study was conducted to treat LNCaP tumors in vivo and Hep3B tumors immediately post mortem. MR elastography was used to analyze tissue stiffness before and after ablation. Treated tissue was excised immediately after each experiment and processed by routine histological analysis. Four prostate cancer tumors and four liver cancer tumors showed, on average, a threefold increase in stiffness due to FUS thermal treatment. Histology showed complete (100%) coagulation necrosis in these cases. These data suggest that MRE may be an effective means to assess tissue ablation.",
author = "Primak, {Svetlana V.} and Glaser, {Kevin J.} and Jinping Lai and Rossman, {Phillip J.} and Yuan Le and Reynolds, {Carol A.} and Roberts, {Lewis R.} and Felmlee, {Joel P.} and Ehman, {Richard L.}",
year = "2006",
language = "English (US)",
isbn = "0791837904",
series = "American Society of Mechanical Engineers, Bioengineering Division (Publication) BED",
publisher = "American Society of Mechanical Engineers (ASME)",
booktitle = "Proceedings of 2006 ASME International Mechanical Engineering Congress and Exposition, IMECE2006 - Bioengineering Division",
note = "2006 ASME International Mechanical Engineering Congress and Exposition, IMECE2006 ; Conference date: 05-11-2006 Through 10-11-2006",
}